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10.1016/j.imbio.2020.151955 http://scihub22266oqcxt.onion/10.1016/j.imbio.2020.151955 32517882!7211625!32517882     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Immunobiology 2020 ; 225 (3): 151955 Nephropedia Template TP {{tp|p=32517882|t=2020. Immunoinformatics-guided designing of epitope-based subunit vaccines against the SARS Coronavirus-2 (SARS-CoV-2) |pdf=|usr=}}{{32517882}} gab.com Text Immunoinformatics-guided designing of epitope-based subunit vaccines against the SARS Coronavirus-2 (SARS-CoV-2) JO: Immunobiology http://www.kidney.de/pget.php?&tw=1&pmid=32517882 #FOAvip SARS Coronavirus-2 (SARS-CoV-2) pandemic has become a global issue which has raised the concern of scientific community to design and discover a counter-measure against this deadly virus. So far, the pandemic has caused the death of hundreds of thousands of people upon infection and spreading. To date, no effective vaccine is available which can combat the infection caused by this virus. Therefore, this study was conducted to design possible epitope-based subunit vaccines against the SARS-CoV-2 virus using the approaches of reverse vaccinology and immunoinformatics. Upon continual computational experimentation, three possible vaccine constructs were designed and one vaccine construct was selected as the best vaccine based on molecular docking study which is supposed to effectively act against the SARS-CoV-2. Thereafter, the molecular dynamics simulation and in silico codon adaptation experiments were carried out in order to check biological stability and find effective mass production strategy of the selected vaccine. This study should contribute to uphold the present efforts of the researches to secure a definitive preventative measure against this lethal disease. Twit Text FOAVip Immunoinformatics-guided designing of epitope-based subunit vaccines against the SARS Coronavirus-2 (SARS-CoV-2) ????Immunobiology http://www.kidney.de/pget.php?&tw=1&pmid=32517882 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32517882 #FOAvip English Wikipedia <ref>{{Cite pmid|32517882}}</ref> Immunoinformatics-guided designing of epitope-based subunit vaccines against the SARS Coronavirus-2 (SARS-CoV-2) #MMPMID32517882 Sarkar B; Ullah MA; Johora FT; Taniya MA; Araf Y Immunobiology 2020[May]; 225 (3): 151955 PMID32517882show ga SARS Coronavirus-2 (SARS-CoV-2) pandemic has become a global issue which has raised the concern of scientific community to design and discover a counter-measure against this deadly virus. So far, the pandemic has caused the death of hundreds of thousands of people upon infection and spreading. To date, no effective vaccine is available which can combat the infection caused by this virus. Therefore, this study was conducted to design possible epitope-based subunit vaccines against the SARS-CoV-2 virus using the approaches of reverse vaccinology and immunoinformatics. Upon continual computational experimentation, three possible vaccine constructs were designed and one vaccine construct was selected as the best vaccine based on molecular docking study which is supposed to effectively act against the SARS-CoV-2. Thereafter, the molecular dynamics simulation and in silico codon adaptation experiments were carried out in order to check biological stability and find effective mass production strategy of the selected vaccine. This study should contribute to uphold the present efforts of the researches to secure a definitive preventative measure against this lethal disease. |*Pandemics[MESH] |Amino Acid Sequence[MESH] |Betacoronavirus/drug effects/*immunology/pathogenicity[MESH] |COVID-19[MESH] |COVID-19 Vaccines[MESH] |Computational Biology/methods[MESH] |Coronavirus Infections/*drug therapy/epidemiology/immunology/prevention & control/virology[MESH] |Disease Progression[MESH] |Epitopes, B-Lymphocyte/genetics/immunology[MESH] |Epitopes, T-Lymphocyte/genetics/immunology[MESH] |Epitopes/chemistry/immunology[MESH] |HLA Antigens/genetics/immunology[MESH] |Host-Pathogen Interactions/genetics/immunology[MESH] |Humans[MESH] |Immunogenicity, Vaccine[MESH] |Molecular Docking Simulation[MESH] |Plasmids/chemistry/immunology[MESH] |Pneumonia, Viral/*drug therapy/epidemiology/immunology/virology[MESH] |Protein Conformation[MESH] |Reverse Genetics/methods[MESH] |SARS-CoV-2[MESH] |Sequence Alignment[MESH] |Vaccines, Subunit[MESH] |Viral Proteins/*chemistry/genetics/immunology[MESH]Immunoinformatics-guided designing of epitope-based subunit vaccines a(epmc).pdf DeepDyve Pubget Overpricing