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10.1111/vox.12968

http://scihub22266oqcxt.onion/10.1111/vox.12968
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32516839!7300975!32516839
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suck abstract from ncbi


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pmid32516839      Vox+Sang 2020 ; 115 (6): 507-514
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  • Early experience with convalescent plasma as immunotherapy for COVID-19 in China: Knowns and unknowns #MMPMID32516839
  • Chen B; Xia R
  • Vox Sang 2020[Aug]; 115 (6): 507-514 PMID32516839show ga
  • BACKGROUND AND OBJECTIVES: In the absence of a vaccine or specific drug treatment options for coronavirus disease (COVID-19), attention has been shifted in China to the possible therapeutic use of convalescent plasma. COVID-19 convalescent plasma (CCP) is currently under investigation. We summarized clinical studies and other research data available as of 5 May 2020 on CCP therapy according to the Clinical Treatment Guideline of COVID-19 Convalescent Plasma in China, as well as clinical experience at the First Affiliated Hospital of Zhejiang University, as part of a comprehensive anti-epidemic strategy. MATERIALS AND METHODS: As of 5 May 2020, when the epidemic was well-controlled in China, healthcare databases and sources of English literature relating to convalescent plasma were searched and reviewed. Sources of clinical and methodological heterogeneity were identified. RESULTS: As of 5 May 2020, up to 2000 samples of CCP had been collected across China and administered to 700 COVID-19 patients. From donors, 200-400 ml of plasma was collected at each donation, with antibody titres > 1:160. We identified three clinical studies for COVID-19 in China. Analyses showed a statistically significant improvement in clinical outcomes compared with untreated cases (P < 0.001). No adverse effects were reported. CONCLUSION: From initial studies, convalescent plasma therapy appears effective and safe for COVID-19. However, there is clearly a need for well-designed RCTs (randomized controlled trials) or other formal studies to further evaluate the efficacy and any potential adverse effects of CCP.
  • |COVID-19[MESH]
  • |COVID-19 Serotherapy[MESH]
  • |China[MESH]
  • |Clinical Trials as Topic[MESH]
  • |Coronavirus Infections/epidemiology/*therapy[MESH]
  • |Humans[MESH]
  • |Immunization, Passive/adverse effects/methods/statistics & numerical data[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/epidemiology/*therapy[MESH]


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