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10.1016/j.mehy.2020.109948 http://scihub22266oqcxt.onion/10.1016/j.mehy.2020.109948 32516733!7264927!32516733     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Med+Hypotheses 2020 ; 144 (ä): 109948 Nephropedia Template TP {{tp|p=32516733|t=2020. B-cell engineering: A promising approach towards vaccine development for COVID-19 |pdf=|usr=}}{{32516733}} gab.com Text B-cell engineering: A promising approach towards vaccine development for COVID-19 JO: Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=32516733 #FOAvip With the number of cases crossing six million (and more than three hundred and seventy thousand deaths) worldwide, there is a dire need of a vaccine (and repurposing of drugs) for SARS-CoV-2 disease (COVID-19). It can be argued that a vaccine may be the most efficient way to contain the spread of this disease and prevent its future onset. While many attempts are being made to design and develop a vaccine for SARS-CoV-2, pertinent technological hitches do exist. That is perhaps one of the reasons that we don't have vaccine for coronaviruses (including SARS-CoV-1 and MERS). Recently developed CRISPR-mediated genome editing approach can be repurposed into a cell-modification endeavor in addition to (and rather than) correcting defective parts of genome. With this premise, B-cells can be engineered into universal donor, antigen specific, perpetually viable, long lasting, non-oncogenic, relatively benign, antibody producing cells which may serve as an effective vaccine for SARS-CoV-2 and, by the same rationale, other viruses and pathogens. Twit Text FOAVip B-cell engineering: A promising approach towards vaccine development for COVID-19 ????Med Hypotheses http://www.kidney.de/pget.php?&tw=1&pmid=32516733 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32516733 #FOAvip English Wikipedia <ref>{{Cite pmid|32516733}}</ref> B-cell engineering: A promising approach towards vaccine development for COVID-19 #MMPMID32516733 Faiq MA Med Hypotheses 2020[Nov]; 144 (ä): 109948 PMID32516733show ga With the number of cases crossing six million (and more than three hundred and seventy thousand deaths) worldwide, there is a dire need of a vaccine (and repurposing of drugs) for SARS-CoV-2 disease (COVID-19). It can be argued that a vaccine may be the most efficient way to contain the spread of this disease and prevent its future onset. While many attempts are being made to design and develop a vaccine for SARS-CoV-2, pertinent technological hitches do exist. That is perhaps one of the reasons that we don't have vaccine for coronaviruses (including SARS-CoV-1 and MERS). Recently developed CRISPR-mediated genome editing approach can be repurposed into a cell-modification endeavor in addition to (and rather than) correcting defective parts of genome. With this premise, B-cells can be engineered into universal donor, antigen specific, perpetually viable, long lasting, non-oncogenic, relatively benign, antibody producing cells which may serve as an effective vaccine for SARS-CoV-2 and, by the same rationale, other viruses and pathogens. |Animals[MESH] |Antibodies, Viral/biosynthesis/genetics[MESH] |B-Lymphocytes/*immunology/virology[MESH] |COVID-19 Vaccines/*biosynthesis/genetics[MESH] |COVID-19/*immunology/*prevention & control/virology[MESH] |Cell Engineering/methods[MESH] |Genetic Engineering/*methods[MESH] |Host Microbial Interactions/genetics/immunology[MESH] |Humans[MESH] |Mice[MESH] |Models, Genetic[MESH] |Models, Immunological[MESH] |Pandemics/prevention & control[MESH]B-cell engineering: A promising approach towards vaccine development f(epmc).pdf DeepDyve Pubget Overpricing