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10.1016/j.cell.2020.05.027 http://scihub22266oqcxt.onion/10.1016/j.cell.2020.05.027 32516571!7241398!32516571     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell 2020 ; 182 (1): 50-58.e8 Nephropedia Template TP {{tp|p=32516571|t=2020. Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2 |pdf=|usr=}}{{32516571}} gab.com Text Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2 JO: Cell http://www.kidney.de/pget.php?&tw=1&pmid=32516571 #FOAvip COVID-19 has spread worldwide since 2019 and is now a severe threat to public health. We previously identified the causative agent as a novel SARS-related coronavirus (SARS-CoV-2) that uses human angiotensin-converting enzyme 2 (hACE2) as the entry receptor. Here, we successfully developed a SARS-CoV-2 hACE2 transgenic mouse (HFH4-hACE2 in C3B6 mice) infection model. The infected mice generated typical interstitial pneumonia and pathology that were similar to those of COVID-19 patients. Viral quantification revealed the lungs as the major site of infection, although viral RNA could also be found in the eye, heart, and brain in some mice. Virus identical to SARS-CoV-2 in full-genome sequences was isolated from the infected lung and brain tissues. Last, we showed that pre-exposure to SARS-CoV-2 could protect mice from severe pneumonia. Our results show that the hACE2 mouse would be a valuable tool for testing potential vaccines and therapeutics. Twit Text FOAVip Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2 ????Cell http://www.kidney.de/pget.php?&tw=1&pmid=32516571 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32516571 #FOAvip English Wikipedia <ref>{{Cite pmid|32516571}}</ref> Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiotensin-Converting Enzyme 2 #MMPMID32516571 Jiang RD; Liu MQ; Chen Y; Shan C; Zhou YW; Shen XR; Li Q; Zhang L; Zhu Y; Si HR; Wang Q; Min J; Wang X; Zhang W; Li B; Zhang HJ; Baric RS; Zhou P; Yang XL; Shi ZL Cell 2020[Jul]; 182 (1): 50-58.e8 PMID32516571show ga COVID-19 has spread worldwide since 2019 and is now a severe threat to public health. We previously identified the causative agent as a novel SARS-related coronavirus (SARS-CoV-2) that uses human angiotensin-converting enzyme 2 (hACE2) as the entry receptor. Here, we successfully developed a SARS-CoV-2 hACE2 transgenic mouse (HFH4-hACE2 in C3B6 mice) infection model. The infected mice generated typical interstitial pneumonia and pathology that were similar to those of COVID-19 patients. Viral quantification revealed the lungs as the major site of infection, although viral RNA could also be found in the eye, heart, and brain in some mice. Virus identical to SARS-CoV-2 in full-genome sequences was isolated from the infected lung and brain tissues. Last, we showed that pre-exposure to SARS-CoV-2 could protect mice from severe pneumonia. Our results show that the hACE2 mouse would be a valuable tool for testing potential vaccines and therapeutics. |*Disease Models, Animal[MESH] |*Mice, Transgenic/genetics[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Betacoronavirus/*physiology[MESH] |COVID-19[MESH] |Coronavirus Infections/*pathology[MESH] |Female[MESH] |Humans[MESH] |Lung Diseases, Interstitial/pathology/virology[MESH] |Male[MESH] |Mice[MESH] |Mice, Inbred C3H[MESH] |Mice, Inbred C57BL[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/genetics[MESH] |Pneumonia, Viral/*pathology[MESH] |SARS-CoV-2[MESH] |Viral Tropism[MESH]Pathogenesis of SARS-CoV-2 in Transgenic Mice Expressing Human Angiot(epmc).pdf DeepDyve Pubget Overpricing