H(2)S as a potential defense against COVID-19? #MMPMID32515982
Yang G
Am J Physiol Cell Physiol 2020[Aug]; 319 (2): C244-C249 PMID32515982show ga
The outbreak of COVID-19 pneumonia caused by a new coronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) is posing a global health emergency and has led to more than 380,000 deaths worldwide. The cell entry of SARS-CoV-2 depends on two host proteins angiotensin-converting enzyme 2 (ACE2) and transmembrane protease serine 2 (TMPRSS2). There is currently no vaccine available and also no effective drug for the treatment of COVID-19. Hydrogen sulfide (H(2)S) as a novel gasotransmitter has been shown to protect against lung damage via its anti-inflammation, antioxidative stress, antiviral, prosurvival, and antiaging effects. In light of the research advances on H(2)S signaling in biology and medicine, this review proposed H(2)S as a potential defense against COVID-19. It is suggested that H(2)S may block SARS-CoV-2 entry into host cells by interfering with ACE2 and TMPRSS2, inhibit SARS-CoV-2 replication by attenuating virus assembly/release, and protect SARS-CoV-2-induced lung damage by suppressing immune response and inflammation development. Preclinical studies and clinical trials with slow-releasing H(2)S donor(s) or the activators of endogenous H(2)S-generating enzymes should be considered as a preventative treatment or therapy for COVID-19.
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Am+J+Physiol+Cell+Physiol 2020 ; 319 (2): C244-C249
