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10.1021/acs.nanolett.0c01723 http://scihub22266oqcxt.onion/10.1021/acs.nanolett.0c01723 32515974!ä!32515974 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nano+Lett 2020 ; 20 (7): 5367-5375 Nephropedia Template TP {{tp|p=32515974|t=2020. Spiky Nanostructures with Geometry-matching Topography for Virus Inhibition |pdf=|usr=}}{{32515974}} gab.com Text Spiky Nanostructures with Geometry-matching Topography for Virus Inhibition JO: Nano Lett http://www.kidney.de/pget.php?&tw=1&pmid=32515974 #FOAvip Geometry-matching has been known to benefit the formation of stable biological interactions in natural systems. Herein, we report that the spiky nanostructures with matched topography to the influenza A virus (IAV) virions could be used to design next-generation advanced virus inhibitors. We demonstrated that nanostructures with spikes between 5 and 10 nm bind significantly better to virions than smooth nanoparticles, due to the short spikes inserting into the gaps of glycoproteins of the IAV virion. Furthermore, an erythrocyte membrane (EM) was coated to target the IAV, and the obtained EM-coated nanostructures could efficiently prevent IAV virion binding to the cells and inhibit subsequent infection. In a postinfection study, the EM-coated nanostructures reduced >99.9% virus replication at the cellular nontoxic dosage. We predict that such a combination of geometry-matching topography and cellular membrane coating will also push forward the development of nanoinhibitors for other virus strains, including SARS-CoV-2. Twit Text FOAVip Spiky Nanostructures with Geometry-matching Topography for Virus Inhibition ????Nano Lett http://www.kidney.de/pget.php?&tw=1&pmid=32515974 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32515974 #FOAvip English Wikipedia <ref>{{Cite pmid|32515974}}</ref> Spiky Nanostructures with Geometry-matching Topography for Virus Inhibition #MMPMID32515974 Nie C; Stadtmuller M; Yang H; Xia Y; Wolff T; Cheng C; Haag R Nano Lett 2020[Jul]; 20 (7): 5367-5375 PMID32515974show ga Geometry-matching has been known to benefit the formation of stable biological interactions in natural systems. Herein, we report that the spiky nanostructures with matched topography to the influenza A virus (IAV) virions could be used to design next-generation advanced virus inhibitors. We demonstrated that nanostructures with spikes between 5 and 10 nm bind significantly better to virions than smooth nanoparticles, due to the short spikes inserting into the gaps of glycoproteins of the IAV virion. Furthermore, an erythrocyte membrane (EM) was coated to target the IAV, and the obtained EM-coated nanostructures could efficiently prevent IAV virion binding to the cells and inhibit subsequent infection. In a postinfection study, the EM-coated nanostructures reduced >99.9% virus replication at the cellular nontoxic dosage. We predict that such a combination of geometry-matching topography and cellular membrane coating will also push forward the development of nanoinhibitors for other virus strains, including SARS-CoV-2. |Antiviral Agents/pharmacology[MESH] |Betacoronavirus/drug effects/*ultrastructure[MESH] |Binding Sites[MESH] |COVID-19[MESH] |Coronavirus Infections/drug therapy/*virology[MESH] |Drug Design[MESH] |Humans[MESH] |Influenza A virus/drug effects/ultrastructure[MESH] |Microscopy, Electron[MESH] |Models, Biological[MESH] |Nanostructures/*ultrastructure[MESH] |Nanotechnology[MESH] |Pandemics[MESH] |Pneumonia, Viral/drug therapy/*virology[MESH] |SARS-CoV-2[MESH] |Spike Glycoprotein, Coronavirus/drug effects/ultrastructure[MESH]Spiky Nanostructures with Geometry-matching Topography for Virus Inhib(epmc).pdf DeepDyve Pubget Overpricing