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10.1002/jmv.26149

http://scihub22266oqcxt.onion/10.1002/jmv.26149
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suck abstract from ncbi


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pmid32515499      J+Med+Virol 2020 ; 92 (11): 2852-2856
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  • Higher levels of IL-6 early after tocilizumab distinguish survivors from nonsurvivors in COVID-19 pneumonia: A possible indication for deeper targeting of IL-6 #MMPMID32515499
  • Quartuccio L; Sonaglia A; Pecori D; Peghin M; Fabris M; Tascini C; De Vita S
  • J Med Virol 2020[Nov]; 92 (11): 2852-2856 PMID32515499show ga
  • INTRODUCTION: The most serious COVID-19 deriving from severe acute respiratory syndrome coronavirus 2 causes a cytokine release storm and it is associated with worse outcomes. In COVID-19 patients, interleukin-6 (IL-6) levels are significantly elevated. Blocking IL-6 preliminarily resulted in the improvement of this hyperinflammatory state. It is unknown which patients could require higher doses of tocilizumab to get out of the cytokine storm. MATERIALS AND METHODS: Twenty-four patients affected by COVID-19 pneumonia were included. All the patients underwent tocilizumab 8 mg/kg intravenously and were tested for serum IL-6 24 to 48 hours before and 12 to 48 hours after tocilizumab infusion. Comparisons between survivors and nonsurvivors were performed. RESULTS: Eighteen patients were discharged, while six patients died, with no clinical or laboratory differences between the two groups at baseline. IL-6 was not different at baseline (P = .41), while 24 to 48 hours post-tocilizumab IL-6 serum levels were significantly higher in nonsurvivors than in survivors (2398.5 [430.5-9372] vs 290.5 [58.5-1305.5] pg/mL, P = .022). Serum IL-6 post-tocilizumab showed a good predictive ability to discriminate survivors from nonsurvivors (area under the curve, 0.815; 95% confidence interval, 0.63-0.99, P = .02). CONCLUSION: Repeated measurement of the serum level of IL-6 early after tocilizumab may distinguish nonsurvivors from survivors and support the choice of deeper targeting IL-6 in COVID-19 pneumonia.
  • |*COVID-19 Drug Treatment[MESH]
  • |Administration, Intravenous[MESH]
  • |Aged[MESH]
  • |Antibodies, Monoclonal, Humanized/*therapeutic use[MESH]
  • |Biomarkers/blood[MESH]
  • |Cytokine Release Syndrome/drug therapy/virology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Interleukin-6/*blood[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Retrospective Studies[MESH]
  • |Severity of Illness Index[MESH]


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