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10.1161/JAHA.120.017529

http://scihub22266oqcxt.onion/10.1161/JAHA.120.017529
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32515253!7660727!32515253
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suck abstract from ncbi


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pmid32515253      J+Am+Heart+Assoc 2020 ; 9 (14): e017529
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  • Guidance on Short-Term Management of Atrial Fibrillation in Coronavirus Disease 2019 #MMPMID32515253
  • Rattanawong P; Shen W; El Masry H; Sorajja D; Srivathsan K; Valverde A; Scott LR
  • J Am Heart Assoc 2020[Jul]; 9 (14): e017529 PMID32515253show ga
  • Atrial fibrillation is a common clinical manifestation in hospitalized patients with coronavirus disease 2019 (COVID-19). Medications used to treat atrial fibrillation, such as antiarrhythmic drugs and anticoagulants, may have significant drug interactions with emerging COVID-19 treatments. Common unintended nontherapeutic target effects of COVID-19 treatment include potassium channel blockade, cytochrome P 450 isoenzyme inhibition or activation, and P-glycoprotein inhibition. Drug-drug interactions with antiarrhythmic drugs and anticoagulants in these patients may lead to significant bradycardia, ventricular arrhythmias, or severe bleeding. It is important for clinicians to be aware of these interactions, drug metabolism changes, and clinical consequences when choosing antiarrhythmic drugs and anticoagulants for COVID-19 patients with atrial fibrillation. The objective of this review is to provide a practical guide for clinicians who are managing COVID-19 patients with concomitant atrial fibrillation.
  • |Anti-Arrhythmia Agents/adverse effects/pharmacokinetics/*therapeutic use[MESH]
  • |Anticoagulants/adverse effects/pharmacokinetics/*therapeutic use[MESH]
  • |Antiviral Agents/adverse effects/pharmacokinetics/*therapeutic use[MESH]
  • |Atrial Fibrillation/diagnosis/epidemiology/*therapy[MESH]
  • |Betacoronavirus/*pathogenicity[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |Coronavirus Infections/diagnosis/*drug therapy/epidemiology/virology[MESH]
  • |Drug Interactions[MESH]
  • |Host Microbial Interactions[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/diagnosis/*drug therapy/epidemiology/virology[MESH]
  • |Risk Assessment[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]


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