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10.1038/s41591-020-0944-y http://scihub22266oqcxt.onion/10.1038/s41591-020-0944-y 32514174!7382903!32514174     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32514174&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Med 2020 ; 26 (7): 1070-1076 Nephropedia Template TP {{tp|p=32514174|t=2020. A single-cell atlas of the peripheral immune response in patients with severe COVID-19 |pdf=|usr=}}{{32514174}} gab.com Text A single-cell atlas of the peripheral immune response in patients with severe COVID-19 JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=32514174 #FOAvip There is an urgent need to better understand the pathophysiology of Coronavirus disease 2019 (COVID-19), the global pandemic caused by SARS-CoV-2, which has infected more than three million people worldwide(1). Approximately 20% of patients with COVID-19 develop severe disease and 5% of patients require intensive care(2). Severe disease has been associated with changes in peripheral immune activity, including increased levels of pro-inflammatory cytokines(3,4) that may be produced by a subset of inflammatory monocytes(5,6), lymphopenia(7,8) and T cell exhaustion(9,10). To elucidate pathways in peripheral immune cells that might lead to immunopathology or protective immunity in severe COVID-19, we applied single-cell RNA sequencing (scRNA-seq) to profile peripheral blood mononuclear cells (PBMCs) from seven patients hospitalized for COVID-19, four of whom had acute respiratory distress syndrome, and six healthy controls. We identify reconfiguration of peripheral immune cell phenotype in COVID-19, including a heterogeneous interferon-stimulated gene signature, HLA class II downregulation and a developing neutrophil population that appears closely related to plasmablasts appearing in patients with acute respiratory failure requiring mechanical ventilation. Importantly, we found that peripheral monocytes and lymphocytes do not express substantial amounts of pro-inflammatory cytokines. Collectively, we provide a cell atlas of the peripheral immune response to severe COVID-19. Twit Text FOAVip A single-cell atlas of the peripheral immune response in patients with severe COVID-19 ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=32514174 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32514174 #FOAvip English Wikipedia <ref>{{Cite pmid|32514174}}</ref> A single-cell atlas of the peripheral immune response in patients with severe COVID-19 #MMPMID32514174 Wilk AJ; Rustagi A; Zhao NQ; Roque J; Martinez-Colon GJ; McKechnie JL; Ivison GT; Ranganath T; Vergara R; Hollis T; Simpson LJ; Grant P; Subramanian A; Rogers AJ; Blish CA Nat Med 2020[Jul]; 26 (7): 1070-1076 PMID32514174show ga There is an urgent need to better understand the pathophysiology of Coronavirus disease 2019 (COVID-19), the global pandemic caused by SARS-CoV-2, which has infected more than three million people worldwide(1). Approximately 20% of patients with COVID-19 develop severe disease and 5% of patients require intensive care(2). Severe disease has been associated with changes in peripheral immune activity, including increased levels of pro-inflammatory cytokines(3,4) that may be produced by a subset of inflammatory monocytes(5,6), lymphopenia(7,8) and T cell exhaustion(9,10). To elucidate pathways in peripheral immune cells that might lead to immunopathology or protective immunity in severe COVID-19, we applied single-cell RNA sequencing (scRNA-seq) to profile peripheral blood mononuclear cells (PBMCs) from seven patients hospitalized for COVID-19, four of whom had acute respiratory distress syndrome, and six healthy controls. We identify reconfiguration of peripheral immune cell phenotype in COVID-19, including a heterogeneous interferon-stimulated gene signature, HLA class II downregulation and a developing neutrophil population that appears closely related to plasmablasts appearing in patients with acute respiratory failure requiring mechanical ventilation. Importantly, we found that peripheral monocytes and lymphocytes do not express substantial amounts of pro-inflammatory cytokines. Collectively, we provide a cell atlas of the peripheral immune response to severe COVID-19. |*Coronavirus Infections/genetics/immunology/pathology[MESH] |*Immunity, Cellular[MESH] |*Leukocytes, Mononuclear/immunology/metabolism/virology[MESH] |*Pandemics[MESH] |*Pneumonia, Viral/genetics/immunology/pathology[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Betacoronavirus/*immunology[MESH] |COVID-19[MESH] |Case-Control Studies[MESH] |Cytokines/genetics/metabolism[MESH] |Female[MESH] |Gene Expression Profiling/methods[MESH] |Humans[MESH] |Killer Cells, Natural/immunology/metabolism[MESH] |Male[MESH] |Middle Aged[MESH] |RNA-Seq/methods[MESH] |SARS-CoV-2[MESH] |Sequence Analysis, RNA/*methods[MESH] |Severity of Illness Index[MESH] |Single-Cell Analysis/*methods[MESH] |T-Lymphocytes/immunology/metabolism[MESH]A single-cell atlas of the peripheral immune response in patients with(epmc).pdf DeepDyve Pubget Overpricing