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10.1038/s41418-020-0572-6

http://scihub22266oqcxt.onion/10.1038/s41418-020-0572-6
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32514047!7278239!32514047
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suck abstract from ncbi


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pmid32514047      Cell+Death+Differ 2020 ; 27 (11): 3196-3207
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  • Expansion of myeloid-derived suppressor cells in patients with severe coronavirus disease (COVID-19) #MMPMID32514047
  • Agrati C; Sacchi A; Bordoni V; Cimini E; Notari S; Grassi G; Casetti R; Tartaglia E; Lalle E; D'Abramo A; Castilletti C; Marchioni L; Shi Y; Mariano A; Song JW; Zhang JY; Wang FS; Zhang C; Fimia GM; Capobianchi MR; Piacentini M; Antinori A; Nicastri E; Maeurer M; Zumla A; Ippolito G
  • Cell Death Differ 2020[Nov]; 27 (11): 3196-3207 PMID32514047show ga
  • SARS-CoV-2 is associated with a 3.4% mortality rate in patients with severe disease. The pathogenesis of severe cases remains unknown. We performed an in-depth prospective analysis of immune and inflammation markers in two patients with severe COVID-19 disease from presentation to convalescence. Peripheral blood from 18 SARS-CoV-2-infected patients, 9 with severe and 9 with mild COVID-19 disease, was obtained at admission and analyzed for T-cell activation profile, myeloid-derived suppressor cells (MDSCs) and cytokine profiles. MDSC functionality was tested in vitro. In four severe and in four mild patients, a longitudinal analysis was performed daily from the day of admission to the early convalescent phase. Early after admission severe patients showed neutrophilia, lymphopenia, increase in effector T cells, a persisting higher expression of CD95 on T cells, higher serum concentration of IL-6 and TGF-beta, and a cytotoxic profile of NK and T cells compared with mild patients, suggesting a highly engaged immune response. Massive expansion of MDSCs was observed, up to 90% of total circulating mononuclear cells in patients with severe disease, and up to 25% in the patients with mild disease; the frequency decreasing with recovery. MDSCs suppressed T-cell functions, dampening excessive immune response. MDSCs decline at convalescent phase was associated to a reduction in TGF-beta and to an increase of inflammatory cytokines in plasma samples. Substantial expansion of suppressor cells is seen in patients with severe COVID-19. Further studies are required to define their roles in reducing the excessive activation/inflammation, protection, influencing disease progression, potential to serve as biomarkers of disease severity, and new targets for immune and host-directed therapeutic approaches.
  • |Adult[MESH]
  • |Betacoronavirus/*pathogenicity[MESH]
  • |CD4-Positive T-Lymphocytes/metabolism[MESH]
  • |CD8-Positive T-Lymphocytes/immunology[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/immunology/*virology[MESH]
  • |Cytokines/metabolism[MESH]
  • |Disease Progression[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Inflammation/immunology[MESH]
  • |Lymphocyte Activation/*immunology[MESH]
  • |Myeloid-Derived Suppressor Cells/*cytology/immunology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/immunology/*virology[MESH]


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