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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Science 2020 ; 369 (6503): 582-587 Nephropedia Template TP
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Genomic surveillance reveals multiple introductions of SARS-CoV-2 into Northern California #MMPMID32513865
Deng X; Gu W; Federman S; du Plessis L; Pybus OG; Faria NR; Wang C; Yu G; Bushnell B; Pan CY; Guevara H; Sotomayor-Gonzalez A; Zorn K; Gopez A; Servellita V; Hsu E; Miller S; Bedford T; Greninger AL; Roychoudhury P; Starita LM; Famulare M; Chu HY; Shendure J; Jerome KR; Anderson C; Gangavarapu K; Zeller M; Spencer E; Andersen KG; MacCannell D; Paden CR; Li Y; Zhang J; Tong S; Armstrong G; Morrow S; Willis M; Matyas BT; Mase S; Kasirye O; Park M; Masinde G; Chan C; Yu AT; Chai SJ; Villarino E; Bonin B; Wadford DA; Chiu CY
Science 2020[Jul]; 369 (6503): 582-587 PMID32513865show ga
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally, with >365,000 cases in California as of 17 July 2020. We investigated the genomic epidemiology of SARS-CoV-2 in Northern California from late January to mid-March 2020, using samples from 36 patients spanning nine counties and the Grand Princess cruise ship. Phylogenetic analyses revealed the cryptic introduction of at least seven different SARS-CoV-2 lineages into California, including epidemic WA1 strains associated with Washington state, with lack of a predominant lineage and limited transmission among communities. Lineages associated with outbreak clusters in two counties were defined by a single base substitution in the viral genome. These findings support contact tracing, social distancing, and travel restrictions to contain the spread of SARS-CoV-2 in California and other states.