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10.1016/j.ebiom.2020.102819 http://scihub22266oqcxt.onion/10.1016/j.ebiom.2020.102819 32512518!7273168!32512518     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32512518&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EBioMedicine 2020 ; 56 (ä): 102819 Nephropedia Template TP {{tp|p=32512518|t=2020. A novel rabies vaccine based on infectious propagating particles derived from hybrid VEEV-Rabies replicon |pdf=|usr=}}{{32512518}} gab.com Text A novel rabies vaccine based on infectious propagating particles derived from hybrid VEEV-Rabies replicon JO: EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=32512518 #FOAvip BACKGROUND: Live attenuated vaccines (LAVs) can mimic natural infection and have advantages to stimulate a robust and sustained immune response as well as to confer long-term protection. However, safety concerns is one of the major obstacles for LAVs development. In an effort to achieve the optimal balance between immunogenicity and safety, researchers currently have taken different strategies for the development of LAVs. METHODS: We constructed a novel infectious self-propagating hybrid replicon particle (PRP), VEEV-RABV-G, through replacing the entire structural proteins of the Venezuelan equine encephalitis virus (VEEV) with the glycoprotein of rabies virus (RABV-G) as the single structural protein. We evaluated the potential of VEEV-RABV-G as a safe live attenuated vaccine in mice model. FINDINGS: We found that VEEV-RABV-G could self-propagate efficiently in cell culture and induce a robust humoral immunity and provide protection against virulent RABV challenge in immunized mice. Remarkably, VEEV-RABV-G is highly attenuated in both adult and sucking mice, causing much weaker inflammatory and apoptotic effects in the brains of infected adult mice and significantly lower weight loss and morbidity compared with the commonly used RABV-derived LAVs. INTERPRETATION: This study reveals the feasibility of developing novel rabies vaccines based on the self-replicating PRPs. FUNDING: This work was supported by the National Key Research and Development Program of China (2016YFD0500400). Twit Text FOAVip A novel rabies vaccine based on infectious propagating particles derived from hybrid VEEV-Rabies replicon ????EBioMedicine http://www.kidney.de/pget.php?&tw=1&pmid=32512518 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32512518 #FOAvip English Wikipedia <ref>{{Cite pmid|32512518}}</ref> A novel rabies vaccine based on infectious propagating particles derived from hybrid VEEV-Rabies replicon #MMPMID32512518 Zhang YN; Chen C; Deng CL; Zhang CG; Li N; Wang Z; Zhao L; Zhang B EBioMedicine 2020[Jun]; 56 (ä): 102819 PMID32512518show ga BACKGROUND: Live attenuated vaccines (LAVs) can mimic natural infection and have advantages to stimulate a robust and sustained immune response as well as to confer long-term protection. However, safety concerns is one of the major obstacles for LAVs development. In an effort to achieve the optimal balance between immunogenicity and safety, researchers currently have taken different strategies for the development of LAVs. METHODS: We constructed a novel infectious self-propagating hybrid replicon particle (PRP), VEEV-RABV-G, through replacing the entire structural proteins of the Venezuelan equine encephalitis virus (VEEV) with the glycoprotein of rabies virus (RABV-G) as the single structural protein. We evaluated the potential of VEEV-RABV-G as a safe live attenuated vaccine in mice model. FINDINGS: We found that VEEV-RABV-G could self-propagate efficiently in cell culture and induce a robust humoral immunity and provide protection against virulent RABV challenge in immunized mice. Remarkably, VEEV-RABV-G is highly attenuated in both adult and sucking mice, causing much weaker inflammatory and apoptotic effects in the brains of infected adult mice and significantly lower weight loss and morbidity compared with the commonly used RABV-derived LAVs. INTERPRETATION: This study reveals the feasibility of developing novel rabies vaccines based on the self-replicating PRPs. FUNDING: This work was supported by the National Key Research and Development Program of China (2016YFD0500400). |Animals[MESH] |Animals, Newborn[MESH] |Cell Line[MESH] |Disease Models, Animal[MESH] |Encephalitis Virus, Venezuelan Equine/genetics/immunology/*physiology[MESH] |Female[MESH] |Immunity, Humoral[MESH] |Mice[MESH] |Rabies Vaccines/*administration & dosage/genetics/immunology[MESH] |Rabies virus/genetics/immunology/*metabolism[MESH] |Rabies/*prevention & control[MESH] |Recombinant Proteins/immunology[MESH] |Vaccines, Attenuated/administration & dosage/genetics/immunology[MESH] |Viral Structural Proteins/genetics/*immunology/metabolism[MESH]A novel rabies vaccine based on infectious propagating particles deriv(epmc).pdf DeepDyve Pubget Overpricing