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10.1016/j.bbapap.2020.140467 http://scihub22266oqcxt.onion/10.1016/j.bbapap.2020.140467 32512181!7274130!32512181     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochim+Biophys+Acta+Proteins+Proteom 2020 ; 1868 (9): 140467 Nephropedia Template TP {{tp|p=32512181|t=2020. Degradation of thymic humoral factor gamma2 in human, rat and mouse blood: An experimental and theoretical study |pdf=|usr=}}{{32512181}} gab.com Text Degradation of thymic humoral factor gamma2 in human, rat and mouse blood: An experimental and theoretical study JO: Biochim Biophys Acta Proteins Proteom http://www.kidney.de/pget.php?&tw=1&pmid=32512181 #FOAvip The degradation of the immunomodulatory octapeptide, thymic humoral factor gamma2 (THF-gamma2, thymoctonan) has been studied in whole blood samples from human, rat and mouse. The peptide, Leu-Glu-Asp-Gly-Pro-Lys-Phe-Leu, was shown to be rapidly degraded by peptidases. The half-life of the intact peptide was less than 6 min at 37 degrees C in blood from the three species tested. The main fragments formed from THF-gamma2 were found to be Glu-Asp-Gly-Pro-Lys-Phe-Leu (2-8), Asp-Gly-Pro-Lys-Phe-Leu (3-8) and Glu-Asp-Gly-Pro-Lys (2-6) in human and in rat blood and 2-8 and 2-6 in mouse blood. Analysis of the time course of degradation revealed a sequential removal of single amino acids from the N-terminus (aminopeptidase activities) in a process that was apparently unable to cleave the Gly-Pro bond (positions 4-5 in the peptide) together with an independent cleavage of the Lys-Phe bond (positions 6-7 in the peptide) to release the dipeptide Phe-Leu. This behaviour and the effects of inhibitors showed the involvement of metallo-exopeptidases in the N-terminal digestion and a phosphoramidon-sensitive metallo-endopeptidase in the cleavage of the Lys-Phe bond. The degradation patterns in human blood were modelled in terms of the competing pathways involved approximating to first-order kinetics, and an analytical solution obtained via the method of Laplace Transforms. The half-life of THF degradation in whole rat blood sample was found to be significantly lower than in human or mouse. Twit Text FOAVip Degradation of thymic humoral factor gamma2 in human, rat and mouse blood: An experimental and theoretical study ????Biochim Biophys Acta Proteins Proteom http://www.kidney.de/pget.php?&tw=1&pmid=32512181 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32512181 #FOAvip English Wikipedia <ref>{{Cite pmid|32512181}}</ref> Degradation of thymic humoral factor gamma2 in human, rat and mouse blood: An experimental and theoretical study #MMPMID32512181 Martignoni M; Benedetti M; Davey GP; Tipton KF; McDonald AG Biochim Biophys Acta Proteins Proteom 2020[Sep]; 1868 (9): 140467 PMID32512181show ga The degradation of the immunomodulatory octapeptide, thymic humoral factor gamma2 (THF-gamma2, thymoctonan) has been studied in whole blood samples from human, rat and mouse. The peptide, Leu-Glu-Asp-Gly-Pro-Lys-Phe-Leu, was shown to be rapidly degraded by peptidases. The half-life of the intact peptide was less than 6 min at 37 degrees C in blood from the three species tested. The main fragments formed from THF-gamma2 were found to be Glu-Asp-Gly-Pro-Lys-Phe-Leu (2-8), Asp-Gly-Pro-Lys-Phe-Leu (3-8) and Glu-Asp-Gly-Pro-Lys (2-6) in human and in rat blood and 2-8 and 2-6 in mouse blood. Analysis of the time course of degradation revealed a sequential removal of single amino acids from the N-terminus (aminopeptidase activities) in a process that was apparently unable to cleave the Gly-Pro bond (positions 4-5 in the peptide) together with an independent cleavage of the Lys-Phe bond (positions 6-7 in the peptide) to release the dipeptide Phe-Leu. This behaviour and the effects of inhibitors showed the involvement of metallo-exopeptidases in the N-terminal digestion and a phosphoramidon-sensitive metallo-endopeptidase in the cleavage of the Lys-Phe bond. The degradation patterns in human blood were modelled in terms of the competing pathways involved approximating to first-order kinetics, and an analytical solution obtained via the method of Laplace Transforms. The half-life of THF degradation in whole rat blood sample was found to be significantly lower than in human or mouse. |Aminopeptidases[MESH] |Animals[MESH] |Dipeptides/chemistry[MESH] |Half-Life[MESH] |Humans[MESH] |Kinetics[MESH] |Male[MESH] |Mice[MESH] |Models, Animal[MESH] |Models, Theoretical[MESH] |Neprilysin/metabolism[MESH] |Oligopeptides/*blood/chemistry/*metabolism[MESH] |Peptide Hydrolases[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Rats[MESH]Degradation of thymic humoral factor gamma2 in human, rat and mouse bl(epmc).pdf DeepDyve Pubget Overpricing