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10.1016/j.addr.2020.06.001 http://scihub22266oqcxt.onion/10.1016/j.addr.2020.06.001 32512029!7274121!32512029     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Adv+Drug+Deliv+Rev 2021 ; 168 (ä): 217-228 Nephropedia Template TP {{tp|p=32512029|t=2021. Inhalation delivery technology for genome-editing of respiratory diseases |pdf=|usr=}}{{32512029}} gab.com Text Inhalation delivery technology for genome-editing of respiratory diseases JO: Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=32512029 #FOAvip The clustered regulatory interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (CRISPR/Cas9) system has significant therapeutic potentials for lung congenital diseases such as cystic fibrosis, as well as other pulmonary disorders like lung cancer and obstructive diseases. Local administration of CRISPR/Cas9 therapeutics through inhalation can achieve high drug concentration and minimise systemic exposure. While the field is advancing with better understanding on the biological functions achieved by CRISPR/Cas9 systems, the lack of progress in inhalation formulation and delivery of the molecule may impede their clinical translation efficiently. This forward-looking review discussed the current status of formulations and delivery for inhalation of relevant biologics such as genes (plasmids and mRNAs) and proteins, emphasising on their design strategies and preparation methods. By adapting and optimising formulation strategies used for genes and proteins, we envisage that development of inhalable CRISPR/Cas9 liquid or powder formulations for inhalation administration can potentially be fast-tracked in near future. Twit Text FOAVip Inhalation delivery technology for genome-editing of respiratory diseases ????Adv Drug Deliv Rev http://www.kidney.de/pget.php?&tw=1&pmid=32512029 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32512029 #FOAvip English Wikipedia <ref>{{Cite pmid|32512029}}</ref> Inhalation delivery technology for genome-editing of respiratory diseases #MMPMID32512029 Chow MYT; Chang RYK; Chan HK Adv Drug Deliv Rev 2021[Jan]; 168 (ä): 217-228 PMID32512029show ga The clustered regulatory interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (CRISPR/Cas9) system has significant therapeutic potentials for lung congenital diseases such as cystic fibrosis, as well as other pulmonary disorders like lung cancer and obstructive diseases. Local administration of CRISPR/Cas9 therapeutics through inhalation can achieve high drug concentration and minimise systemic exposure. While the field is advancing with better understanding on the biological functions achieved by CRISPR/Cas9 systems, the lack of progress in inhalation formulation and delivery of the molecule may impede their clinical translation efficiently. This forward-looking review discussed the current status of formulations and delivery for inhalation of relevant biologics such as genes (plasmids and mRNAs) and proteins, emphasising on their design strategies and preparation methods. By adapting and optimising formulation strategies used for genes and proteins, we envisage that development of inhalable CRISPR/Cas9 liquid or powder formulations for inhalation administration can potentially be fast-tracked in near future. |Administration, Inhalation[MESH] |Aerosols/*administration & dosage/*pharmacokinetics[MESH] |Chemistry, Pharmaceutical/*methods[MESH] |Clustered Regularly Interspaced Short Palindromic Repeats[MESH] |Drug Compounding[MESH] |Drug Stability[MESH] |Gene Editing[MESH] |Genetic Therapy/*methods[MESH] |Humans[MESH] |Particle Size[MESH] |Plasmids/administration & dosage[MESH] |Proteins/administration & dosage[MESH] |RNA, Messenger/administration & dosage[MESH]Inhalation delivery technology for genome-editing of respiratory disea(epmc).pdf DeepDyve Pubget Overpricing