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10.1016/j.cca.2020.06.013

http://scihub22266oqcxt.onion/10.1016/j.cca.2020.06.013
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32511972!7274122!32511972
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suck abstract from ncbi


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pmid32511972      Clin+Chim+Acta 2020 ; 509 (ä): 91-94
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  • C-reactive protein: A promising biomarker for poor prognosis in COVID-19 infection #MMPMID32511972
  • Sahu BR; Kampa RK; Padhi A; Panda AK
  • Clin Chim Acta 2020[Oct]; 509 (ä): 91-94 PMID32511972show ga
  • BACKGROUND: The novel coronavirus disease 2019 (COVID-19) first broke out in Wuhan, China, spread over 227 countries and caused approximately 0.3 million death worldwide. Several biomolecules have been explored for possible biomarkers for prognosis outcome. Although increased C reactive protein (CRP) is associated with death due to COVID-19 infections, results from different populations remain inconsistent. For a conclusive result, the present meta-analysis was performed. METHODS: We conducted a literature search in PubMed and Scopus database for the association of CRP concentration with COVID-19 disease outcomes. A total of 16 eligible studies were enrolled in the present analysis comprising of 1896 survivors and 849 non-survivors cases. Concentrations of CRP were compared and analyzed by a meta-analysis. RESULTS: Egger's regression analysis (intercept = 0.04, P = 0.98, 95%CI = -5.48 to 5.58) and funnel plot revealed an absence of publication bias in the included studies. Due to the presence of significant heterogeneity across the studies (Q = 252.03, P(heterogeneity) = 0.000, I(2) = 93.65) random model was used for the analysis of the present study. The results of the meta-analysis demonstrated a significant role of CRP in COVID-19 infection outcome (Standard difference in means = 1.371, P = 0.000). CONCLUSIONS: Concentrations of CRP remained high in patients who died of COVID-19 infection and could be a promising biomarker for assessing disease lethality.
  • |*Betacoronavirus[MESH]
  • |Biomarkers/blood[MESH]
  • |C-Reactive Protein/*metabolism[MESH]
  • |COVID-19[MESH]
  • |Cohort Studies[MESH]
  • |Coronavirus Infections/*blood/*diagnosis/epidemiology[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*blood/*diagnosis/epidemiology[MESH]
  • |Prognosis[MESH]


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