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10.1101/2020.04.17.20069930 http://scihub22266oqcxt.onion/10.1101/2020.04.17.20069930 32511639!7276995!32511639     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32511639&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32511639.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       medRxiv 2020 ; ä (ä): ä Nephropedia Template TP {{tp|p=32511639|t=2020. A single-cell atlas of the peripheral immune response to severe COVID-19 |pdf=|usr=}}{{32511639}} gab.com Text A single-cell atlas of the peripheral immune response to severe COVID-19 JO: medRxiv http://www.kidney.de/pget.php?&tw=1&pmid=32511639 #FOAvip There is an urgent need to better understand the pathophysiology of Coronavirus disease 2019 (COVID-19), the global pandemic caused by SARS-CoV-2. Here, we apply single-cell RNA sequencing (scRNA-seq) to peripheral blood mononuclear cells (PBMCs) of 7 patients hospitalized with confirmed COVID-19 and 6 healthy controls. We identify substantial reconfiguration of peripheral immune cell phenotype in COVID-19, including a heterogeneous interferon-stimulated gene (ISG) signature, HLA class II downregulation, and a novel B cell-derived granulocyte population appearing in patients with acute respiratory failure requiring mechanical ventilation. Importantly, peripheral monocytes and lymphocytes do not express substantial amounts of pro-inflammatory cytokines, suggesting that circulating leukocytes do not significantly contribute to the potential COVID-19 cytokine storm. Collectively, we provide the most thorough cell atlas to date of the peripheral immune response to severe COVID-19. Twit Text FOAVip A single-cell atlas of the peripheral immune response to severe COVID-19 ????medRxiv http://www.kidney.de/pget.php?&tw=1&pmid=32511639 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32511639 #FOAvip English Wikipedia <ref>{{Cite pmid|32511639}}</ref> A single-cell atlas of the peripheral immune response to severe COVID-19 #MMPMID32511639 Wilk AJ; Rustagi A; Zhao NQ; Roque J; Martinez-Colon GJ; McKechnie JL; Ivison GT; Ranganath T; Vergara R; Hollis T; Simpson LJ; Grant P; Subramanian A; Rogers AJ; Blish CA medRxiv 2020[Apr]; ä (ä): ä PMID32511639show ga There is an urgent need to better understand the pathophysiology of Coronavirus disease 2019 (COVID-19), the global pandemic caused by SARS-CoV-2. Here, we apply single-cell RNA sequencing (scRNA-seq) to peripheral blood mononuclear cells (PBMCs) of 7 patients hospitalized with confirmed COVID-19 and 6 healthy controls. We identify substantial reconfiguration of peripheral immune cell phenotype in COVID-19, including a heterogeneous interferon-stimulated gene (ISG) signature, HLA class II downregulation, and a novel B cell-derived granulocyte population appearing in patients with acute respiratory failure requiring mechanical ventilation. Importantly, peripheral monocytes and lymphocytes do not express substantial amounts of pro-inflammatory cytokines, suggesting that circulating leukocytes do not significantly contribute to the potential COVID-19 cytokine storm. Collectively, we provide the most thorough cell atlas to date of the peripheral immune response to severe COVID-19. äA single-cell atlas of the peripheral immune response to severe COVID-(epmc).pdf DeepDyve Pubget Overpricing