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10.1111/dth.13785

http://scihub22266oqcxt.onion/10.1111/dth.13785
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suck abstract from ncbi


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pmid32510734      Dermatol+Ther 2020 ; 33 (4): e13785
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  • Azithromycin and COVID-19: Prompt early use at first signs of this infection in adults and children, an approach worthy of consideration #MMPMID32510734
  • Schwartz RA; Suskind RM
  • Dermatol Ther 2020[Jul]; 33 (4): e13785 PMID32510734show ga
  • The devastating effects of the coronavirus designated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have led to urgent attempts to find effective therapeutic agents for inpatient and outpatient treatment of COVID-19. Initial enthusiasm for the combination of hydroxychloroquine and azithromycin has abated. However, as a result of positive clinical experience with azithromycin used alone during the first few days of the flu-like illness caused by this coronavirus, we recommend formal clinical trials using azithromycin early in the course of a COVID-19 infection. There is one clinical trial initiated, the individually randomized, telemedicine-based, "Azithromycin for COVID-19 Treatment in Outpatients Nationwide" based at the University of California San Francisco. This placebo-controlled trial is designed to determine the efficacy of a single 1.2-g dose of oral azithromycin to prevent COVID-19 patient progression to hospitalization. We recommend formal clinical trials of azithromycin in its prepackaged form at the first sign of COVID-19 infection in adults and children, using an initial adult dose of 500 mg followed by 250 mg per day for 4 days, a total cumulative dose of 1.5 g, and for children 5 to 18 years of age, 10 mg/kg on the first day followed by 5 mg/kg for 4 days.
  • |*Betacoronavirus[MESH]
  • |Adult[MESH]
  • |Anti-Bacterial Agents/therapeutic use[MESH]
  • |Azithromycin/*therapeutic use[MESH]
  • |COVID-19[MESH]
  • |Child[MESH]
  • |Coronavirus Infections/*drug therapy/epidemiology[MESH]
  • |Dose-Response Relationship, Drug[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/epidemiology[MESH]


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