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10.7554/eLife.57093 http://scihub22266oqcxt.onion/10.7554/eLife.57093 32510332!7347390!32510332     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32510332&cmd=llinks): Failed to open stream: HTTP request failed! 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Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling in C elegans |pdf=|usr=}}{{32510332}} gab.com Text Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling in C elegans JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=32510332 #FOAvip Animal behaviors are commonly organized into long-lasting states that coordinately impact the generation of diverse motor outputs such as feeding, locomotion, and grooming. However, the neural mechanisms that coordinate these distinct motor programs remain poorly understood. Here, we examine how the distinct motor programs of the nematode C. elegans are coupled together across behavioral states. We describe a new imaging platform that permits automated, simultaneous quantification of each of the main C. elegans motor programs over hours or days. Analysis of these whole-organism behavioral profiles shows that the motor programs coordinately change as animals switch behavioral states. Utilizing genetics, optogenetics, and calcium imaging, we identify a new role for dopamine in coupling locomotion and egg-laying together across states. These results provide new insights into how the diverse motor programs throughout an organism are coordinated and suggest that neuromodulators like dopamine can couple motor circuits together in a state-dependent manner. Twit Text FOAVip Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling in C elegans ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=32510332 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32510332 #FOAvip English Wikipedia <ref>{{Cite pmid|32510332}}</ref> Whole-organism behavioral profiling reveals a role for dopamine in state-dependent motor program coupling in C elegans #MMPMID32510332 Cermak N; Yu SK; Clark R; Huang YC; Baskoylu SN; Flavell SW Elife 2020[Jun]; 9 (ä): ä PMID32510332show ga Animal behaviors are commonly organized into long-lasting states that coordinately impact the generation of diverse motor outputs such as feeding, locomotion, and grooming. However, the neural mechanisms that coordinate these distinct motor programs remain poorly understood. Here, we examine how the distinct motor programs of the nematode C. elegans are coupled together across behavioral states. We describe a new imaging platform that permits automated, simultaneous quantification of each of the main C. elegans motor programs over hours or days. Analysis of these whole-organism behavioral profiles shows that the motor programs coordinately change as animals switch behavioral states. Utilizing genetics, optogenetics, and calcium imaging, we identify a new role for dopamine in coupling locomotion and egg-laying together across states. These results provide new insights into how the diverse motor programs throughout an organism are coordinated and suggest that neuromodulators like dopamine can couple motor circuits together in a state-dependent manner. |Animals[MESH] |Behavior, Animal/*physiology[MESH] |Caenorhabditis elegans/classification/*physiology[MESH] |Dopamine/*metabolism[MESH] |Motor Activity/*physiology[MESH]Whole-organism behavioral profiling reveals a role for dopamine in st(epmc).pdf DeepDyve Pubget Overpricing