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10.1042/BST20200505 http://scihub22266oqcxt.onion/10.1042/BST20200505 32510142!ä!32510142 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32510142&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Soc+Trans 2020 ; 48 (3): 1287-1295 Nephropedia Template TP {{tp|p=32510142|t=2020. alpha-glucosidase inhibitors as host-directed antiviral agents with potential for the treatment of COVID-19 |pdf=|usr=}}{{32510142}} gab.com Text alpha-glucosidase inhibitors as host-directed antiviral agents with potential for the treatment of COVID-19 JO: Biochem Soc Trans http://www.kidney.de/pget.php?&tw=1&pmid=32510142 #FOAvip The ongoing COVID-19 pandemic, caused by SARS-CoV-2, has pushed the health systems of many countries to breaking point and precipitated social distancing measures that have crippled economic activities across the globe. A return to normality is unlikely until effective therapeutics and a vaccine are available. The immediacy of this problem suggests that drug strategies should focus on repurposing approved drugs or late-stage clinical candidates, as these have the shortest path to use in the clinic. Here, we review and discuss the role of host cell N-glycosylation pathways to virus replication and the drugs available to disrupt these pathways. In particular, we make a case for evaluation of the well-tolerated drugs miglitol, celgosivir and especially miglustat for the treatment of COVID-19. Twit Text FOAVip alpha-glucosidase inhibitors as host-directed antiviral agents with potential for the treatment of COVID-19 ????Biochem Soc Trans http://www.kidney.de/pget.php?&tw=1&pmid=32510142 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32510142 #FOAvip English Wikipedia <ref>{{Cite pmid|32510142}}</ref> alpha-glucosidase inhibitors as host-directed antiviral agents with potential for the treatment of COVID-19 #MMPMID32510142 Williams SJ; Goddard-Borger ED Biochem Soc Trans 2020[Jun]; 48 (3): 1287-1295 PMID32510142show ga The ongoing COVID-19 pandemic, caused by SARS-CoV-2, has pushed the health systems of many countries to breaking point and precipitated social distancing measures that have crippled economic activities across the globe. A return to normality is unlikely until effective therapeutics and a vaccine are available. The immediacy of this problem suggests that drug strategies should focus on repurposing approved drugs or late-stage clinical candidates, as these have the shortest path to use in the clinic. Here, we review and discuss the role of host cell N-glycosylation pathways to virus replication and the drugs available to disrupt these pathways. In particular, we make a case for evaluation of the well-tolerated drugs miglitol, celgosivir and especially miglustat for the treatment of COVID-19. |Antiviral Agents/*pharmacology/therapeutic use[MESH] |Betacoronavirus/*chemistry[MESH] |COVID-19[MESH] |Calnexin/metabolism[MESH] |Coronavirus Infections/drug therapy/*metabolism/virology[MESH] |Drug Repositioning/*methods[MESH] |Glycoside Hydrolase Inhibitors/*pharmacology/therapeutic use[MESH] |Glycosylation/drug effects[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Pandemics[MESH] |Pneumonia, Viral/drug therapy/*metabolism/virology[MESH] |Protein Folding/drug effects[MESH] |SARS-CoV-2[MESH] |Spike Glycoprotein, Coronavirus/metabolism[MESH] |Virus Replication/drug effects[MESH]alpha-glucosidase inhibitors as host-directed antiviral agents with po(epmc).pdf DeepDyve Pubget Overpricing