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10.1038/s41541-020-0193-6 http://scihub22266oqcxt.onion/10.1038/s41541-020-0193-6 32509338!7248068!32509338     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       NPJ+Vaccines 2020 ; 5 (1): 42 Nephropedia Template TP {{tp|p=32509338|t=2020. Certainty of success: three critical parameters in coronavirus vaccine development |pdf=|usr=}}{{32509338}} gab.com Text Certainty of success: three critical parameters in coronavirus vaccine development JO: NPJ Vaccines http://www.kidney.de/pget.php?&tw=1&pmid=32509338 #FOAvip Vaccines for 17 viral pathogens have been licensed for use in humans. Previously, two critical biological parameters of the pathogen and the host-pathogen interaction-incubation period and broadly protective, relative immunogenicity-were proposed to account for much of the past successes in vaccine development, and to be useful in estimating the "certainty of success" of developing an effective vaccine for viral pathogens for which a vaccine currently does not exist. In considering the "certainty of success" in development of human coronavirus vaccines, particularly SARS-CoV-2, a third, related critical parameter is proposed-infectious inoculum intensity, at an individual-level, and force of infection, at a population-level. Reducing the infectious inoculum intensity (and force of infection, at a population-level) is predicted to lengthen the incubation period, which in turn is predicted to reduce the severity of illness, and increase the opportunity for an anamnestic response upon exposure to the circulating virus. Similarly, successfully implementing individual- and population-based behaviors that reduce the infectious inoculum intensity and force of infection, respectively, while testing and deploying COVID-19 vaccines is predicted to increase the "certainty of success" of demonstrating vaccine efficacy and controlling SARS-CoV-2 infection, disease, death, and the pandemic itself. Twit Text FOAVip Certainty of success: three critical parameters in coronavirus vaccine development ????NPJ Vaccines http://www.kidney.de/pget.php?&tw=1&pmid=32509338 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32509338 #FOAvip English Wikipedia <ref>{{Cite pmid|32509338}}</ref> Certainty of success: three critical parameters in coronavirus vaccine development #MMPMID32509338 Kaslow DC NPJ Vaccines 2020[]; 5 (1): 42 PMID32509338show ga Vaccines for 17 viral pathogens have been licensed for use in humans. Previously, two critical biological parameters of the pathogen and the host-pathogen interaction-incubation period and broadly protective, relative immunogenicity-were proposed to account for much of the past successes in vaccine development, and to be useful in estimating the "certainty of success" of developing an effective vaccine for viral pathogens for which a vaccine currently does not exist. In considering the "certainty of success" in development of human coronavirus vaccines, particularly SARS-CoV-2, a third, related critical parameter is proposed-infectious inoculum intensity, at an individual-level, and force of infection, at a population-level. Reducing the infectious inoculum intensity (and force of infection, at a population-level) is predicted to lengthen the incubation period, which in turn is predicted to reduce the severity of illness, and increase the opportunity for an anamnestic response upon exposure to the circulating virus. Similarly, successfully implementing individual- and population-based behaviors that reduce the infectious inoculum intensity and force of infection, respectively, while testing and deploying COVID-19 vaccines is predicted to increase the "certainty of success" of demonstrating vaccine efficacy and controlling SARS-CoV-2 infection, disease, death, and the pandemic itself. äCertainty of success: three critical parameters in coronavirus vaccine(epmc).pdf DeepDyve Pubget Overpricing