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10.1002/jcla.23392

http://scihub22266oqcxt.onion/10.1002/jcla.23392
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suck abstract from ncbi


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pmid32506726      J+Clin+Lab+Anal 2020 ; 34 (7): e23392
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  • Clinical features of COVID-19 convalescent patients with re-positive nucleic acid detection #MMPMID32506726
  • Zhu H; Fu L; Jin Y; Shao J; Zhang S; Zheng N; Fan L; Yu Z; Ying J; Hu Y; Chen T; Chen Y; Chen M; Chen M; Xiong Z; Kang J; Jin J; Cai T; Ye H
  • J Clin Lab Anal 2020[Jul]; 34 (7): e23392 PMID32506726show ga
  • BACKGROUND: Coronavirus disease 2019 (COVID-19) is a pandemic that has rapidly spread worldwide. Increasingly, confirmed patients being discharged according to the current diagnosis and treatment protocols, follow-up of convalescent patients is important to knowing about the outcome. METHODS: A retrospective study was performed among 98 convalescent patients with COVID-19 in a single medical center. The clinical features of patients during their hospitalization and 2-week postdischarge quarantine were collected. RESULTS: Among the 98 COVID-19 convalescent patients, 17 (17.3%) were detected positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid during 2-week postdischarge quarantine. The median time from discharge to SARS-CoV-2 nucleic acid re-positive was 4 days (IQR, 3-8.5).The median time from symptoms onset to final respiratory SARS-CoV-2 detection of negative result was significantly longer in re-positive group (34 days [IQR, 29.5-42.5]) than in non-re-positive group (19 days [IQR, 16-26]). On the other hand, the levels of CD3-CD56 + NK cells during hospitalization and 2-week postdischarge were higher in re-positive group than in non-re-positive group (repeated measures ANOVA, P = .018). However, only one case in re-positive group showed exudative lesion recurrence in pulmonary computed tomography (CT) with recurred symptoms. CONCLUSION: It is still possible for convalescent patients to show positive for SARS-CoV-2 nucleic acid detection, but most of the re-positive patients showed no deterioration in pulmonary CT findings. Continuous quarantine and close follow-up for convalescent patients are necessary to prevent possible relapse and spread of the disease to some extent.
  • |*Convalescence[MESH]
  • |Adult[MESH]
  • |Betacoronavirus/*physiology[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*diagnosis/diagnostic imaging/immunology/virology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Nucleic Acids/*analysis[MESH]
  • |Pandemics[MESH]
  • |Patient Discharge[MESH]
  • |Pneumonia, Viral/*diagnosis/diagnostic imaging/immunology/virology[MESH]
  • |SARS-CoV-2[MESH]
  • |Thorax/diagnostic imaging[MESH]
  • |Tomography, X-Ray Computed[MESH]


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