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10.1002/cyto.a.24047

http://scihub22266oqcxt.onion/10.1002/cyto.a.24047
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32506725!7300451!32506725
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suck abstract from ncbi


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pmid32506725      Cytometry+A 2020 ; 97 (7): 662-667
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  • Dengue Fever, COVID-19 (SARS-CoV-2), and Antibody-Dependent Enhancement (ADE): A Perspective #MMPMID32506725
  • Ulrich H; Pillat MM; Tarnok A
  • Cytometry A 2020[Jul]; 97 (7): 662-667 PMID32506725show ga
  • SARS-CoV-2 pandemic and recurrent dengue epidemics in tropical countries have turned into a global health threat. While both virus-caused infections may only reveal light symptoms, they can also cause severe diseases. Here, we review the possible antibody-dependent enhancement (ADE) occurrence, known for dengue infections, when there is a second infection with a different virus strain. Consequently, preexisting antibodies do not neutralize infection, but enhance it, possibly by triggering Fcgamma receptor-mediated virus uptake. No clinical data exist indicating such mechanism for SARS-CoV-2, but previous coronavirus infections or infection of SARS-CoV-2 convalescent with different SARS-CoV-2 strains could promote ADE, as experimentally shown for antibodies against the MERS-CoV or SARS-CoV spike S protein. (c) 2020 International Society for Advancement of Cytometry.
  • |Antibody-Dependent Enhancement/*immunology[MESH]
  • |Betacoronavirus/*immunology[MESH]
  • |COVID-19[MESH]
  • |Coinfection/*immunology[MESH]
  • |Coronavirus Infections/immunology/pathology[MESH]
  • |Dengue Virus/*immunology[MESH]
  • |Dengue/immunology/pathology[MESH]
  • |Humans[MESH]
  • |Image Cytometry/methods[MESH]
  • |Middle East Respiratory Syndrome Coronavirus/immunology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/immunology/pathology[MESH]
  • |Receptors, IgG/*immunology[MESH]
  • |SARS-CoV-2[MESH]
  • |Severe acute respiratory syndrome-related coronavirus/immunology[MESH]
  • |Spike Glycoprotein, Coronavirus/*immunology[MESH]


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