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10.1002/ana.25807

http://scihub22266oqcxt.onion/10.1002/ana.25807
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32506549!7300753!32506549
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suck abstract from ncbi

pmid32506549      Ann+Neurol 2020 ; 88 (1): 1-11
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  • COVID-19: A Global Threat to the Nervous System #MMPMID32506549
  • Koralnik IJ; Tyler KL
  • Ann Neurol 2020[Jul]; 88 (1): 1-11 PMID32506549show ga
  • In less than 6 months, the severe acute respiratory syndrome-coronavirus type 2 (SARS-CoV-2) has spread worldwide infecting nearly 6 million people and killing over 350,000. Initially thought to be restricted to the respiratory system, we now understand that coronavirus disease 2019 (COVID-19) also involves multiple other organs, including the central and peripheral nervous system. The number of recognized neurologic manifestations of SARS-CoV-2 infection is rapidly accumulating. These may result from a variety of mechanisms, including virus-induced hyperinflammatory and hypercoagulable states, direct virus infection of the central nervous system (CNS), and postinfectious immune mediated processes. Example of COVID-19 CNS disease include encephalopathy, encephalitis, acute disseminated encephalomyelitis, meningitis, ischemic and hemorrhagic stroke, venous sinus thrombosis, and endothelialitis. In the peripheral nervous system, COVID-19 is associated with dysfunction of smell and taste, muscle injury, the Guillain-Barre syndrome, and its variants. Due to its worldwide distribution and multifactorial pathogenic mechanisms, COVID-19 poses a global threat to the entire nervous system. Although our understanding of SARS-CoV-2 neuropathogenesis is still incomplete and our knowledge is evolving rapidly, we hope that this review will provide a useful framework and help neurologists in understanding the many neurologic facets of COVID-19. ANN NEUROL 2020;88:1-11 ANN NEUROL 2020;88:1-11.
  • |*Betacoronavirus[MESH]
  • |Brain Diseases/etiology/physiopathology[MESH]
  • |Brain Ischemia/etiology/physiopathology[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/complications/*physiopathology[MESH]
  • |Disseminated Intravascular Coagulation/etiology/physiopathology[MESH]
  • |Encephalitis/etiology/physiopathology[MESH]
  • |Encephalomyelitis, Acute Disseminated/etiology/physiopathology[MESH]
  • |Guillain-Barre Syndrome/etiology/physiopathology[MESH]
  • |Humans[MESH]
  • |Inflammation[MESH]
  • |Intracranial Hemorrhages/etiology/physiopathology[MESH]
  • |Leukoencephalitis, Acute Hemorrhagic/etiology/physiopathology[MESH]
  • |Meningitis, Viral/etiology/physiopathology[MESH]
  • |Nervous System Diseases/etiology/*physiopathology[MESH]
  • |Olfaction Disorders/etiology/physiopathology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/complications/*physiopathology[MESH]
  • |SARS-CoV-2[MESH]
  • |Sinus Thrombosis, Intracranial/etiology/physiopathology[MESH]
  • |Stroke/etiology/physiopathology[MESH]


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