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Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Gerontol+A+Biol+Sci+Med+Sci 2020 ; 75 (9): 1796-1800 Nephropedia Template TP
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Clinical Characteristics of Hospitalized Individuals Dying With COVID-19 by Age Group in Italy #MMPMID32506122
Palmieri L; Vanacore N; Donfrancesco C; Lo Noce C; Canevelli M; Punzo O; Raparelli V; Pezzotti P; Riccardo F; Bella A; Fabiani M; D'Ancona FP; Vaianella L; Tiple D; Colaizzo E; Palmer K; Rezza G; Piccioli A; Brusaferro S; Onder G
J Gerontol A Biol Sci Med Sci 2020[Sep]; 75 (9): 1796-1800 PMID32506122show ga
BACKGROUND: Aim of the present study is to describe characteristics of COVID-19-related deaths and to compare the clinical phenotype and course of COVID-19-related deaths occurring in adults (<65 years) and older adults (>/=65 years). METHOD: Medical charts of 3,032 patients dying with COVID-19 in Italy (368 aged < 65 years and 2,664 aged >/=65 years) were revised to extract information on demographics, preexisting comorbidities, and in-hospital complications leading to death. RESULTS: Older adults (>/=65 years) presented with a higher number of comorbidities compared to those aged <65 years (3.3 +/- 1.9 vs 2.5 +/- 1.8, p < .001). Prevalence of ischemic heart disease, atrial fibrillation, heart failure, stroke, hypertension, dementia, COPD, and chronic renal failure was higher in older patients (>/=65 years), while obesity, chronic liver disease, and HIV infection were more common in younger adults (<65 years); 10.9% of younger patients (<65 years) had no comorbidities, compared to 3.2% of older patients (>/=65 years). The younger adults had a higher rate of non-respiratory complications than older patients, including acute renal failure (30.0% vs 20.6%), acute cardiac injury (13.5% vs 10.3%), and superinfections (30.9% vs 9.8%). CONCLUSIONS: Individuals dying with COVID-19 present with high levels of comorbidities, irrespective of age group, but a small proportion of deaths occur in healthy adults with no preexisting conditions. Non-respiratory complications are common, suggesting that the treatment of respiratory conditions needs to be combined with strategies to prevent and mitigate the effects of non-respiratory complications.