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10.1016/j.jneuroim.2020.577282

http://scihub22266oqcxt.onion/10.1016/j.jneuroim.2020.577282
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32505908!7256606!32505908
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suck abstract from ncbi


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pmid32505908      J+Neuroimmunol 2020 ; 345 (ä): 577282
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  • Immunologic characterization of a immunosuppressed multiple sclerosis patient that recovered from SARS-CoV-2 infection #MMPMID32505908
  • Chiarini M; Paghera S; Moratto D; Rossi N; Giacomelli M; Badolato R; Capra R; Imberti L
  • J Neuroimmunol 2020[Aug]; 345 (ä): 577282 PMID32505908show ga
  • A multiple sclerosis patient infected by SARS-CoV-2 during fingolimod therapy was hospitalized with moderate clinical features, and recovered in 15 days. High levels of CCL5 and CCL10 chemokines and of antibody-secreting B cells were detected, while the levels other B- and T-cell subsets were comparable to that of appropriate controls. However, CD4+ and CD8+ cells were oligoclonally expanded and prone to apoptosis when stimulated in vitro. This study suggests that fingolimod-immunosuppressed patients, despite the low circulating lymphocytes, may rapidly expand antibody-secreting cells and mount an effective immune response that favors COVID-19 recovery after drug discontinuation.
  • |*Immunocompromised Host[MESH]
  • |Betacoronavirus[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*complications/*immunology[MESH]
  • |Female[MESH]
  • |Fingolimod Hydrochloride/therapeutic use[MESH]
  • |Humans[MESH]
  • |Immunosuppressive Agents/therapeutic use[MESH]
  • |Middle Aged[MESH]
  • |Multiple Sclerosis, Relapsing-Remitting/drug therapy/*immunology/*virology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications/*immunology[MESH]


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