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10.1016/j.biopha.2020.110316 http://scihub22266oqcxt.onion/10.1016/j.biopha.2020.110316 32505821!7260557!32505821     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32505821&cmd=llinks): Failed to open stream: HTTP request failed! 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Analysis of the molecular mechanism of Pudilan (PDL) treatment for COVID-19 by network pharmacology tools |pdf=|usr=}}{{32505821}} gab.com Text Analysis of the molecular mechanism of Pudilan (PDL) treatment for COVID-19 by network pharmacology tools JO: Biomed Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=32505821 #FOAvip BACKGROUND: Pudilan (PDL), a four-herb prescription with the traditional function of heat-clearing and detoxifying, has been clinically used as an anti-SARS-CoV-2 infectory agent in China. PDL might also have therapeutic potentials for COVID-19 while the underlying mechanisms remain to be clarified. METHODS: We used network pharmacology analysis and selected 68 co-targeted genes/proteins as targets of both PDL and COVID-19. These co-targeted genes/proteins were predicted by SwissDock Server for their high-precision docking simulation, and analyzed by STRING for proteins to protein interaction (PPI), pathway and GO (gene ontology) enrichment. The therapeutic effect for PDL treatment on COVID-19 was validated by the TCMATCOV (TCM Anti COVID-19) platform. RESULTS: PDL might prevent the entrance of SARS-CoV-2 entry into cells by blocking the angiotensin-converting enzyme 2 (ACE2). It might inhibit the cytokine storm by affecting C-reactive protein (CRP), interferon-gamma (IFN-gamma), interleukin- 6 (IL-6), interleukin- 10 (IL-10), tumor necrosis factor (TNF), epidermal growth factor receptor (EGFR), C-C motif chemokine ligand 5 (CCL5), transforming growth factor-beta1 (TGFbeta1), and other proteins. PDL might moderate the immune system to shorten the course of the disease, delay disease progression, and reduce the mortality rate. CONCLUSION: PDL might have a therapeutic effect on COVID-19 through three aspects, including the moderate immune system, anti-inflammation, and anti-virus entry into cells. Twit Text FOAVip Analysis of the molecular mechanism of Pudilan (PDL) treatment for COVID-19 by network pharmacology tools ????Biomed Pharmacother http://www.kidney.de/pget.php?&tw=1&pmid=32505821 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32505821 #FOAvip English Wikipedia <ref>{{Cite pmid|32505821}}</ref> Analysis of the molecular mechanism of Pudilan (PDL) treatment for COVID-19 by network pharmacology tools #MMPMID32505821 Kong Q; Wu Y; Gu Y; Lv Q; Qi F; Gong S; Chen X Biomed Pharmacother 2020[Aug]; 128 (ä): 110316 PMID32505821show ga BACKGROUND: Pudilan (PDL), a four-herb prescription with the traditional function of heat-clearing and detoxifying, has been clinically used as an anti-SARS-CoV-2 infectory agent in China. PDL might also have therapeutic potentials for COVID-19 while the underlying mechanisms remain to be clarified. METHODS: We used network pharmacology analysis and selected 68 co-targeted genes/proteins as targets of both PDL and COVID-19. These co-targeted genes/proteins were predicted by SwissDock Server for their high-precision docking simulation, and analyzed by STRING for proteins to protein interaction (PPI), pathway and GO (gene ontology) enrichment. The therapeutic effect for PDL treatment on COVID-19 was validated by the TCMATCOV (TCM Anti COVID-19) platform. RESULTS: PDL might prevent the entrance of SARS-CoV-2 entry into cells by blocking the angiotensin-converting enzyme 2 (ACE2). It might inhibit the cytokine storm by affecting C-reactive protein (CRP), interferon-gamma (IFN-gamma), interleukin- 6 (IL-6), interleukin- 10 (IL-10), tumor necrosis factor (TNF), epidermal growth factor receptor (EGFR), C-C motif chemokine ligand 5 (CCL5), transforming growth factor-beta1 (TGFbeta1), and other proteins. PDL might moderate the immune system to shorten the course of the disease, delay disease progression, and reduce the mortality rate. CONCLUSION: PDL might have a therapeutic effect on COVID-19 through three aspects, including the moderate immune system, anti-inflammation, and anti-virus entry into cells. |*Betacoronavirus/drug effects/isolation & purification[MESH] |*Coronavirus Infections/drug therapy/immunology[MESH] |*Cytokine Release Syndrome/drug therapy/immunology[MESH] |*Pandemics[MESH] |*Pneumonia, Viral/drug therapy/immunology[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Angiotensin-Converting Enzyme Inhibitors/pharmacology[MESH] |Anti-Inflammatory Agents/pharmacology[MESH] |Antiviral Agents/*pharmacology[MESH] |COVID-19[MESH] |Drugs, Chinese Herbal/*pharmacology[MESH] |Humans[MESH] |Immunologic Factors/pharmacology[MESH] |Interferon-gamma/immunology[MESH] |Interleukins/immunology[MESH] |Molecular Docking Simulation[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Protein Interaction Maps[MESH] |SARS-CoV-2[MESH] |Transforming Growth Factor beta/immunology[MESH]Analysis of the molecular mechanism of Pudilan (PDL) treatment for COV(epmc).pdf DeepDyve Pubget Overpricing