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10.1016/j.mehy.2020.109947

http://scihub22266oqcxt.onion/10.1016/j.mehy.2020.109947
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32505070!7833589!32505070
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suck abstract from ncbi

pmid32505070      Med+Hypotheses 2020 ; 144 (ä): 109947
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  • Nebulized Lidocaine in COVID-19, An Hypothesis #MMPMID32505070
  • Ali ZA; El-Mallakh RS
  • Med Hypotheses 2020[Nov]; 144 (ä): 109947 PMID32505070show ga
  • Coronavirus Diseases-2019 (COVID-19) has caused a large global outbreak and has been declared as a pandemic by the World Health Organization (WHO). It has been proposed that COVID-19-related hyperinflammation and dysregulated immune response might play a critical role in developing a cytokine storm which usually progresses to a life-threatening acute lung injury or acute respiratory distress syndrome in infected individuals. Lidocaine, a local analgesic and anti-arrhythmic, is known for its anti-inflammatory actions and has been used to reduce cough and improve respiratory symptoms in severe asthmatic patients. It has a demonstrated safety profile. It is proposed that nebulized lidocaine might be beneficial in reducing cytokines, protecting patients' lungs and improving outcomes in COVID-19 patients when administered via inhalation as an adjunctive treatment for severe respiratory symptoms in patients fighting the novel Coronavirus. Additional investigation is warranted.
  • |*COVID-19 Drug Treatment[MESH]
  • |*Models, Biological[MESH]
  • |Administration, Inhalation[MESH]
  • |Anesthetics, Local/administration & dosage[MESH]
  • |Anti-Inflammatory Agents/administration & dosage[MESH]
  • |COVID-19/complications/immunology[MESH]
  • |Cytokine Release Syndrome/drug therapy/etiology/immunology[MESH]
  • |Humans[MESH]
  • |Lidocaine/*administration & dosage[MESH]
  • |Nebulizers and Vaporizers[MESH]
  • |Pandemics[MESH]


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