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10.21873/invivo.11949

http://scihub22266oqcxt.onion/10.21873/invivo.11949
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32503817!8378021!32503817
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suck abstract from ncbi


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pmid32503817      In+Vivo 2020 ; 34 (3 Suppl): 1597-1602
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  • Potential Antiviral Drugs for SARS-Cov-2 Treatment: Preclinical Findings and Ongoing Clinical Research #MMPMID32503817
  • Bimonte S; Crispo A; Amore A; Celentano E; Cuomo A; Cascella M
  • In Vivo 2020[Jun]; 34 (3 Suppl): 1597-1602 PMID32503817show ga
  • Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), initially termed 2019-new CoV (2019-nCoV), is a novel coronavirus responsible for the severe respiratory illness currently ongoing worldwide from the beginning of December 2019. This beta gene virus, very close to bat coronaviruses (bat-CoV-RaTG13) and bat-SL-CoVZC45, causes a severe disease, similar to those caused by Middle East respiratory syndrome (MERS)-CoV and SARS-CoV viruses, featured by low to moderate mortality rate. Unfortunately, the antiviral drugs commonly used in clinical practice to treat viral infections, are not applicable to SARS-Cov-2 and no vaccine is available. Thus, it is extremely necessary to identify new drugs suitable for the treatment of the 2019-nCoV outbreak. Different preclinical studies conducted on other coronaviruses suggested that promising clinical outcomes for 2019-nCoV should be obtained by using alpha-interferon, chloroquine phosphate, arabinol, remdesivir, lopinavir/ritonavir, and anti-inflammatory drugs. Moreover, clinical trials with these suitable drugs should be performed on patients affected by SARS-Cov-2 to prove their efficacy and safety. Finally, a very promising therapeutic drug, tocilizumab, is discussed; it is currently used to treat patients presenting COVID-19 pneumonia. Herein, we recapitulate these experimental studies to highlight the use of antiviral drugs for the treatment of SARS-Cov-2 disease.
  • |*Pandemics[MESH]
  • |Adenosine Monophosphate/analogs & derivatives/therapeutic use[MESH]
  • |Alanine/analogs & derivatives/therapeutic use[MESH]
  • |Animals[MESH]
  • |Antibodies, Monoclonal, Humanized/therapeutic use[MESH]
  • |Antiviral Agents/administration & dosage/pharmacology/*therapeutic use[MESH]
  • |Betacoronavirus/drug effects[MESH]
  • |COVID-19[MESH]
  • |Chloroquine/analogs & derivatives/therapeutic use[MESH]
  • |Clinical Trials as Topic[MESH]
  • |Coronavirus Infections/complications/*drug therapy/epidemiology/veterinary[MESH]
  • |Drug Combinations[MESH]
  • |Drug Evaluation, Preclinical[MESH]
  • |Drug Synergism[MESH]
  • |Drug Therapy, Combination[MESH]
  • |Drugs, Investigational/therapeutic use[MESH]
  • |Humans[MESH]
  • |Indoles/therapeutic use[MESH]
  • |Lopinavir/therapeutic use[MESH]
  • |Multicenter Studies as Topic[MESH]
  • |Neuraminidase/antagonists & inhibitors[MESH]
  • |Pneumonia, Viral/complications/*drug therapy/epidemiology[MESH]
  • |Primates[MESH]
  • |Ribavirin/therapeutic use[MESH]
  • |Ritonavir/therapeutic use[MESH]
  • |SARS-CoV-2[MESH]


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