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10.21873/invivo.11947

http://scihub22266oqcxt.onion/10.21873/invivo.11947
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32503815!8378032!32503815
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suck abstract from ncbi


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pmid32503815      In+Vivo 2020 ; 34 (3 Suppl): 1589-1592
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  • Role of Interleukin-6 in Lung Complications in Patients With COVID-19: Therapeutic Implications #MMPMID32503815
  • Smetana K Jr; Brabek J
  • In Vivo 2020[Jun]; 34 (3 Suppl): 1589-1592 PMID32503815show ga
  • COVID-19 is viral respiratory infection with frequently fatal lung complications in the elderly or in people with serious comorbidities. Lung destruction appears to be associated with a cytokine storm related to an increased level of interleukin-6 (IL6). Therapeutic targeting of the interleukin-6 signaling pathway can attenuate such a cytokine storm and can be beneficial for patients with COVID-19 in danger of pulmonary failure. This article demonstrates the importance of IL6 in progression of disease and the possibility of inhibition of IL6 signaling in COVID-19 therapy.
  • |Anti-Inflammatory Agents/therapeutic use[MESH]
  • |Antibodies, Monoclonal, Humanized/therapeutic use[MESH]
  • |Antibodies, Monoclonal/therapeutic use[MESH]
  • |Antiviral Agents/therapeutic use[MESH]
  • |COVID-19[MESH]
  • |Clinical Trials as Topic[MESH]
  • |Coronavirus Infections/*complications/drug therapy/immunology/physiopathology[MESH]
  • |Cytokine Receptor gp130/antagonists & inhibitors/physiology[MESH]
  • |Cytokine Release Syndrome/drug therapy/*etiology/immunology/physiopathology[MESH]
  • |Humans[MESH]
  • |Immunotherapy[MESH]
  • |Indoles/therapeutic use[MESH]
  • |Interleukin-6/antagonists & inhibitors/*physiology[MESH]
  • |Lung/pathology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*complications/drug therapy/immunology/physiopathology[MESH]
  • |Receptors, Interleukin-6/antagonists & inhibitors/physiology[MESH]
  • |Receptors, Virus/drug effects[MESH]


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