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10.21873/invivo.11946

http://scihub22266oqcxt.onion/10.21873/invivo.11946
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32503814!8378025!32503814
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suck abstract from ncbi


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pmid32503814      In+Vivo 2020 ; 34 (3 Suppl): 1567-1588
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  • COVID-19: The Potential Role of Copper and N-acetylcysteine (NAC) in a Combination of Candidate Antiviral Treatments Against SARS-CoV-2 #MMPMID32503814
  • Andreou A; Trantza S; Filippou D; Sipsas N; Tsiodras S
  • In Vivo 2020[Jun]; 34 (3 Suppl): 1567-1588 PMID32503814show ga
  • BACKGROUND: On March 11, 2020, the World Health Organization (WHO) declared the outbreak of coronavirus disease (COVID-19) a pandemic. Since then, thousands of people have suffered and died, making the need for a treatment of severe acute respiratory syndrome-related coronavirus-2 (SARS-CoV-2) more crucial than ever. MATERIALS AND METHODS: The authors carried out a search in PubMed, ClinicalTrials.gov and New England Journal of Medicine (NEJM) for COVID-19 to provide information on the most promising treatments against SARS-CoV-2. RESULTS: Possible COVID-19 agents with promising efficacy and favorable safety profile were identified. The results support the combination of copper, N-acetylcysteine (NAC), colchicine and nitric oxide (NO) with candidate antiviral agents, remdesivir or EIDD-2801, as a treatment for patients positive for SARS-CoV-2. CONCLUSION: The authors propose to study the effects of the combination of copper, NAC, colchicine, NO and currently used experimental antiviral agents, remdesivir or EIDD-2801, as a potential treatment scheme for SARS-COV-2.
  • |Acetylcysteine/administration & dosage/pharmacology/*therapeutic use[MESH]
  • |Adenosine Monophosphate/administration & dosage/*analogs & derivatives/pharmacology/therapeutic use[MESH]
  • |Adjuvants, Immunologic/administration & dosage/therapeutic use[MESH]
  • |Alanine/administration & dosage/*analogs & derivatives/pharmacology/therapeutic use[MESH]
  • |Anti-Inflammatory Agents/administration & dosage/therapeutic use[MESH]
  • |Antiviral Agents/administration & dosage/pharmacology/*therapeutic use[MESH]
  • |Autophagy/drug effects[MESH]
  • |Betacoronavirus/drug effects/physiology[MESH]
  • |COVID-19[MESH]
  • |Colchicine/administration & dosage/pharmacology/*therapeutic use[MESH]
  • |Copper/administration & dosage/*therapeutic use[MESH]
  • |Coronavirus Infections/*drug therapy/immunology/physiopathology[MESH]
  • |Cytidine/analogs & derivatives[MESH]
  • |Drug Synergism[MESH]
  • |Drug Therapy, Combination[MESH]
  • |Humans[MESH]
  • |Hydroxylamines[MESH]
  • |Inflammation[MESH]
  • |Nitric Oxide/administration & dosage/pharmacology/*therapeutic use[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*drug therapy/immunology/physiopathology[MESH]
  • |Prodrugs/administration & dosage/therapeutic use[MESH]
  • |Ribonucleosides/administration & dosage/pharmacology/*therapeutic use[MESH]
  • |SARS-CoV-2[MESH]
  • |Virus Internalization/drug effects[MESH]


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