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10.7861/clinmed.2020-0301

http://scihub22266oqcxt.onion/10.7861/clinmed.2020-0301
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32503801!7385774!32503801
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suck abstract from ncbi


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pmid32503801      Clin+Med+(Lond) 2020 ; 20 (4): e107-e108
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  • Does vitamin D deficiency increase the severity of COVID-19? #MMPMID32503801
  • Weir EK; Thenappan T; Bhargava M; Chen Y
  • Clin Med (Lond) 2020[Jul]; 20 (4): e107-e108 PMID32503801show ga
  • The severity of coronavirus 2019 infection (COVID-19) is determined by the presence of pneumonia, severe acute respiratory distress syndrome (SARS-CoV-2), myocarditis, microvascular thrombosis and/or cytokine storms, all of which involve underlying inflammation. A principal defence against uncontrolled inflammation, and against viral infection in general, is provided by T regulatory lymphocytes (Tregs). Treg levels have been reported to be low in many COVID-19 patients and can be increased by vitamin D supplementation. Low vitamin D levels have been associated with an increase in inflammatory cytokines and a significantly increased risk of pneumonia and viral upper respiratory tract infections. Vitamin D deficiency is associated with an increase in thrombotic episodes, which are frequently observed in COVID-19. Vitamin D deficiency has been found to occur more frequently in patients with obesity and diabetes. These conditions are reported to carry a higher mortality in COVID-19. If vitamin D does in fact reduce the severity of COVID-19 in regard to pneumonia/ARDS, inflammation, inflammatory cytokines and thrombosis, it is our opinion that supplements would offer a relatively easy option to decrease the impact of the pandemic.
  • |*Betacoronavirus[MESH]
  • |*Patient Acuity[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/complications/immunology/*therapy[MESH]
  • |Dietary Supplements[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/complications/immunology/*therapy[MESH]
  • |SARS-CoV-2[MESH]
  • |T-Lymphocytes, Regulatory[MESH]
  • |Vitamin D Deficiency/complications/*drug therapy[MESH]
  • |Vitamin D/*therapeutic use[MESH]


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