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10.1016/j.breast.2020.05.006

http://scihub22266oqcxt.onion/10.1016/j.breast.2020.05.006
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suck abstract from ncbi


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pmid32502796      Breast 2020 ; 52 (ä): 110-115
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  • Changes in breast cancer management during the Corona Virus Disease 19 pandemic: An international survey of the European Breast Cancer Research Association of Surgical Trialists (EUBREAST) #MMPMID32502796
  • Gasparri ML; Gentilini OD; Lueftner D; Kuehn T; Kaidar-Person O; Poortmans P
  • Breast 2020[Aug]; 52 (ä): 110-115 PMID32502796show ga
  • BACKGROUND: Corona Virus Disease 19 (COVID-19) had a worldwide negative impact on healthcare systems, which were not used to coping with such pandemic. Adaptation strategies prioritizing COVID-19 patients included triage of patients and reduction or re-allocation of other services. The aim of our survey was to provide a real time international snapshot of modifications of breast cancer management during the COVID-19 pandemic. METHODS: A survey was developed by a multidisciplinary group on behalf of European Breast Cancer Research Association of Surgical Trialists and distributed via breast cancer societies. One reply per breast unit was requested. RESULTS: In ten days, 377 breast centres from 41 countries completed the questionnaire. RT-PCR testing for SARS-CoV-2 prior to treatment was reported by 44.8% of the institutions. The estimated time interval between diagnosis and treatment initiation increased for about 20% of institutions. Indications for primary systemic therapy were modified in 56% (211/377), with upfront surgery increasing from 39.8% to 50.7% (p < 0.002) and from 33.7% to 42.2% (p < 0.016) in T1cN0 triple-negative and ER-negative/HER2-positive cases, respectively. Sixty-seven percent considered that chemotherapy increases risks for developing COVID-19 complications. Fifty-one percent of the responders reported modifications in chemotherapy protocols. Gene-expression profile used to evaluate the need for adjuvant chemotherapy increased in 18.8%. In luminal-A tumours, a large majority (68%) recommended endocrine treatment to postpone surgery. Postoperative radiation therapy was postponed in 20% of the cases. CONCLUSIONS: Breast cancer management was considerably modified during the COVID-19 pandemic. Our data provide a base to investigate whether these changes impact oncologic outcomes.
  • |Antineoplastic Agents, Hormonal/*therapeutic use[MESH]
  • |Antineoplastic Agents, Immunological/*therapeutic use[MESH]
  • |Antineoplastic Agents/therapeutic use[MESH]
  • |Betacoronavirus[MESH]
  • |Breast Neoplasms/*therapy[MESH]
  • |COVID-19[MESH]
  • |COVID-19 Testing[MESH]
  • |COVID-19 Vaccines[MESH]
  • |Chemotherapy, Adjuvant[MESH]
  • |Clinical Laboratory Techniques[MESH]
  • |Coronavirus Infections/diagnosis/*epidemiology[MESH]
  • |Delivery of Health Care/methods[MESH]
  • |Disease Management[MESH]
  • |Europe/epidemiology[MESH]
  • |Gene Expression Profiling[MESH]
  • |Humans[MESH]
  • |Mass Screening[MESH]
  • |Mastectomy/*methods[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/diagnosis/*epidemiology[MESH]
  • |Radiotherapy, Adjuvant[MESH]
  • |Radiotherapy/*methods[MESH]
  • |SARS-CoV-2[MESH]
  • |Surveys and Questionnaires[MESH]
  • |Time-to-Treatment/statistics & numerical data[MESH]


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