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10.1016/j.cmi.2020.05.026

http://scihub22266oqcxt.onion/10.1016/j.cmi.2020.05.026
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32502645!7265826!32502645
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suck abstract from ncbi


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pmid32502645      Clin+Microbiol+Infect 2020 ; 26 (9): 1236-1241
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  • New-onset anosmia and ageusia in adult patients diagnosed with SARS-CoV-2 infection #MMPMID32502645
  • Patel A; Charani E; Ariyanayagam D; Abdulaal A; Denny SJ; Mughal N; Moore LSP
  • Clin Microbiol Infect 2020[Sep]; 26 (9): 1236-1241 PMID32502645show ga
  • OBJECTIVES: We investigated the prevalence of anosmia and ageusia in adult patients with a laboratory-confirmed diagnosis of infection with severe acute respiratory distress syndrome coronavirus-2 (SARS-CoV-2). METHODS: This was a retrospective observational analysis of patients infected with SARS-CoV-2 admitted to hospital or managed in the community and their household contacts across a London population during the period March 1st to April 1st, 2020. Symptomatology and duration were extracted from routinely collected clinical data and follow-up telephone consultations. Descriptive statistics were used. RESULTS: Of 386 patients, 141 (92 community patients, 49 discharged inpatients) were included for analysis; 77/141 (55%) reported anosmia and ageusia, nine reported only ageusia and three only anosmia. The median onset of anosmia in relation to onset of SARS-CoV-2 disease (COVID-19) symptoms (as defined by the Public Health England case definition) was 4 days (interquartile range (IQR) 5). Median duration of anosmia was 8 days (IQR 16). Median duration of COVID-19 symptoms in community patients was 10 days (IQR 8) versus 18 days (IQR 13.5) in admitted patients. As of April 1, 45 patients had ongoing COVID-19 symptoms and/or anosmia; 107/141 (76%) patients had household contacts, and of 185 non-tested household contacts 79 (43%) had COVID-19 symptoms with 46/79 (58%) reporting anosmia. Six household contacts had anosmia only. CONCLUSIONS: Over half of the positive patients reported anosmia and ageusia, suggesting that these should be added to the case definition and used to guide self-isolation protocols. This adaptation may be integral to case findings in the absence of population-level testing. Until we have successful population-level vaccination coverage, these steps remain critical in the current and future waves of this pandemic.
  • |Adult[MESH]
  • |Aged[MESH]
  • |Aged, 80 and over[MESH]
  • |Ageusia/*virology[MESH]
  • |Anosmia/*virology[MESH]
  • |COVID-19/*complications[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |London/epidemiology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Retrospective Studies[MESH]


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