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10.18632/aging.103415 http://scihub22266oqcxt.onion/10.18632/aging.103415 32501810!7346072!32501810     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Aging+(Albany+NY) 2020 ; 12 (11): 10087-10098 Nephropedia Template TP {{tp|p=32501810|t=2020. ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy |pdf=|usr=}}{{32501810}} gab.com Text ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy JO: Aging (Albany NY) http://www.kidney.de/pget.php?&tw=1&pmid=32501810 #FOAvip As the outbreak of coronavirus disease 2019 (COVID-19) progresses, prognostic markers for early identification of high-risk individuals are an urgent medical need. Italy has one of the highest numbers of SARS-CoV-2-related deaths and one of the highest mortality rates. Worldwide, a more severe course of COVID-19 is associated with older age, comorbidities, and male sex. Hence, we searched for possible genetic components of COVID-19 severity among Italians by looking at expression levels and variants in ACE2 and TMPRSS2 genes, crucial for viral infection.Exome and SNP-array data from a large Italian cohort were used to compare the rare-variants burden and polymorphisms frequency with Europeans and East Asians. Moreover, we looked into gene expression databases to check for sex-unbalanced expression.While we found no significant evidence that ACE2 is associated with disease severity/sex bias, TMPRSS2 levels and genetic variants proved to be possible candidate disease modulators, prompting for rapid experimental validations on large patient cohorts. Twit Text FOAVip ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy ????Aging (Albany NY) http://www.kidney.de/pget.php?&tw=1&pmid=32501810 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32501810 #FOAvip English Wikipedia <ref>{{Cite pmid|32501810}}</ref> ACE2 and TMPRSS2 variants and expression as candidates to sex and country differences in COVID-19 severity in Italy #MMPMID32501810 Asselta R; Paraboschi EM; Mantovani A; Duga S Aging (Albany NY) 2020[Jun]; 12 (11): 10087-10098 PMID32501810show ga As the outbreak of coronavirus disease 2019 (COVID-19) progresses, prognostic markers for early identification of high-risk individuals are an urgent medical need. Italy has one of the highest numbers of SARS-CoV-2-related deaths and one of the highest mortality rates. Worldwide, a more severe course of COVID-19 is associated with older age, comorbidities, and male sex. Hence, we searched for possible genetic components of COVID-19 severity among Italians by looking at expression levels and variants in ACE2 and TMPRSS2 genes, crucial for viral infection.Exome and SNP-array data from a large Italian cohort were used to compare the rare-variants burden and polymorphisms frequency with Europeans and East Asians. Moreover, we looked into gene expression databases to check for sex-unbalanced expression.While we found no significant evidence that ACE2 is associated with disease severity/sex bias, TMPRSS2 levels and genetic variants proved to be possible candidate disease modulators, prompting for rapid experimental validations on large patient cohorts. |Angiotensin-Converting Enzyme 2[MESH] |COVID-19[MESH] |Cohort Studies[MESH] |Coronavirus Infections/*genetics[MESH] |Female[MESH] |Genetic Predisposition to Disease[MESH] |Humans[MESH] |Male[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/*genetics/metabolism[MESH] |Pneumonia, Viral/*genetics[MESH] |Polymorphism, Single Nucleotide[MESH]ACE2 and TMPRSS2 variants and expression as candidates to sex and coun(epmc).pdf DeepDyve Pubget Overpricing