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10.1016/j.xcrm.2020.100019 http://scihub22266oqcxt.onion/10.1016/j.xcrm.2020.100019 32501455!7252041!32501455     free     free     free       Cell+Rep+Med 2020 ; 1 (2): 100019 Nephropedia Template TP {{tp|p=32501455|t=2020. Down Syndrome and COVID-19: A Perfect Storm?|pdf=|usr=}}{{32501455}} gab.com Text Down Syndrome and COVID-19: A Perfect Storm JO: Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=32501455 #FOAvip People with Down syndrome show signs of chronic immune dysregulation, including a higher prevalence of autoimmune disorders, increased rates of hospitalization during respiratory viral infections, and higher mortality rates from pneumonia and sepsis. At the molecular and cellular levels, they show markers of chronic autoinflammation, including interferon hyperactivity, elevated levels of many inflammatory cytokines and chemokines, and changes in diverse immune cell types reminiscent of inflammatory conditions observed in the general population. However, the impact of this immune dysregulation in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and CoV disease of 2019 (COVID-19) remains unknown. This Perspective outlines why individuals with Down syndrome should be considered an at-risk population for severe COVID-19. Specifically, the immune dysregulation caused by trisomy 21 may result in an exacerbated cytokine release syndrome relative to that observed in the euploid population, thus justifying additional monitoring and specialized care for this vulnerable population. Twit Text FOAVip Down Syndrome and COVID-19: A Perfect Storm ????Cell Rep Med http://www.kidney.de/pget.php?&tw=1&pmid=32501455 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32501455 #FOAvip English Wikipedia <ref>{{Cite pmid|32501455}}</ref> Down Syndrome and COVID-19: A Perfect Storm? #MMPMID32501455 Espinosa JM Cell Rep Med 2020[May]; 1 (2): 100019 PMID32501455show ga People with Down syndrome show signs of chronic immune dysregulation, including a higher prevalence of autoimmune disorders, increased rates of hospitalization during respiratory viral infections, and higher mortality rates from pneumonia and sepsis. At the molecular and cellular levels, they show markers of chronic autoinflammation, including interferon hyperactivity, elevated levels of many inflammatory cytokines and chemokines, and changes in diverse immune cell types reminiscent of inflammatory conditions observed in the general population. However, the impact of this immune dysregulation in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and CoV disease of 2019 (COVID-19) remains unknown. This Perspective outlines why individuals with Down syndrome should be considered an at-risk population for severe COVID-19. Specifically, the immune dysregulation caused by trisomy 21 may result in an exacerbated cytokine release syndrome relative to that observed in the euploid population, thus justifying additional monitoring and specialized care for this vulnerable population. |Bacterial Infections/immunology[MESH] |COVID-19/*immunology[MESH] |Coinfection[MESH] |Cytokine Release Syndrome/*immunology[MESH] |Cytokines/immunology/metabolism[MESH] |Down Syndrome/*immunology[MESH] |Humans[MESH] |Inflammation[MESH] |Interferons/immunology/metabolism[MESH]Down Syndrome and COVID-19: A Perfect Storm?(epmc).pdf DeepDyve Pubget Overpricing