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10.2217/pgs-2020-0048 http://scihub22266oqcxt.onion/10.2217/pgs-2020-0048 32501190!7373206!32501190     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Pharmacogenomics 2020 ; 21 (10): 695-703 Nephropedia Template TP {{tp|p=32501190|t=2020. ACE2 and COVID-19: using antihypertensive medications and pharmacogenetic considerations |pdf=|usr=}}{{32501190}} gab.com Text ACE2 and COVID-19: using antihypertensive medications and pharmacogenetic considerations JO: Pharmacogenomics http://www.kidney.de/pget.php?&tw=1&pmid=32501190 #FOAvip COVID-19 utilizes the ACE2 pathway as a means of infection. Early data on COVID-19 suggest heterogeneity in the severity of symptoms during transmission and infection ranging from no symptoms to death. The source of this heterogeneity is likely multifaceted and may have a genetic component. Demographic and clinical comorbidities associated with the severity of infection suggest that possible variants known to influence the renin-angiotensin-aldosterone (RAAS) system pathway (particularly those that influence ACE2) may contribute to the heterogenous infection response. ACE2 and Ang(1-7) (the product of ACE2) seem to have a protective effect on the pulmonary and cardiac systems. Hypertension medication modulation, may alter ACE2 and Ang(1-7), particularly in variants that have been shown to influence RAAS system function, which could be clinically useful in patients with COVID-19. Twit Text FOAVip ACE2 and COVID-19: using antihypertensive medications and pharmacogenetic considerations ????Pharmacogenomics http://www.kidney.de/pget.php?&tw=1&pmid=32501190 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32501190 #FOAvip English Wikipedia <ref>{{Cite pmid|32501190}}</ref> ACE2 and COVID-19: using antihypertensive medications and pharmacogenetic considerations #MMPMID32501190 Snyder EM; Johnson BD Pharmacogenomics 2020[Jul]; 21 (10): 695-703 PMID32501190show ga COVID-19 utilizes the ACE2 pathway as a means of infection. Early data on COVID-19 suggest heterogeneity in the severity of symptoms during transmission and infection ranging from no symptoms to death. The source of this heterogeneity is likely multifaceted and may have a genetic component. Demographic and clinical comorbidities associated with the severity of infection suggest that possible variants known to influence the renin-angiotensin-aldosterone (RAAS) system pathway (particularly those that influence ACE2) may contribute to the heterogenous infection response. ACE2 and Ang(1-7) (the product of ACE2) seem to have a protective effect on the pulmonary and cardiac systems. Hypertension medication modulation, may alter ACE2 and Ang(1-7), particularly in variants that have been shown to influence RAAS system function, which could be clinically useful in patients with COVID-19. |*Pharmacogenetics[MESH] |Angiotensin II Type 1 Receptor Blockers/*therapeutic use[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Antihypertensive Agents/*therapeutic use[MESH] |COVID-19[MESH] |Coronavirus Infections/*drug therapy/*genetics[MESH] |Humans[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/*drug effects/*genetics[MESH] |Pharmacogenomic Testing[MESH] |Pneumonia, Viral/*drug therapy/*genetics[MESH]ACE2 and COVID-19: using antihypertensive medications and pharmacogene(epmc).pdf DeepDyve Pubget Overpricing