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10.1007/s12192-020-01126-9 http://scihub22266oqcxt.onion/10.1007/s12192-020-01126-9 32500379!7271958!32500379     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Stress+Chaperones 2020 ; 25 (5): 707-710 Nephropedia Template TP {{tp|p=32500379|t=2020. COVID-19 and heme oxygenase: novel insight into the disease and potential therapies |pdf=|usr=}}{{32500379}} gab.com Text COVID-19 and heme oxygenase: novel insight into the disease and potential therapies JO: Cell Stress Chaperones http://www.kidney.de/pget.php?&tw=1&pmid=32500379 #FOAvip The COVID-19 pandemic needs therapies that are presently available and safe. We propose that subjects with metabolic syndrome, old age, and male gender have the greatest morbidity and mortality and have low stress proteins, in particular, low intracellular heme oxygenase (HO-1), making them particularly vulnerable to the disease. Additionally, COVID-19's heme reduction may contribute to even lower HO-1. Low-grade inflammation associated with these risk factors contributes to triggering a cytokine storm that spreads to multi-organ failure and near death. The high mortality of those treated with ventilator assistance may partially be explained by ventilator-induced inflammation. The cytoprotective and anti-inflammatory properties of HO-1 can limit the infection's damage. A paradox of COVID-19 hospital admissions data suggests that fewer cigarette-smokers are admitted compared with non-smokers in the general population. This unexpected observation may result from smoke induction of HO-1. Therapies with anti-viral properties that raise HO-1 include certain anesthetics (sevoflurane or isoflurane), hemin, estrogen, statins, curcumin, resveratrol, and melatonin. Controlled trials of these HO-1 inducers should be done in order to prevent or treat COVID-19 disease. Twit Text FOAVip COVID-19 and heme oxygenase: novel insight into the disease and potential therapies ????Cell Stress Chaperones http://www.kidney.de/pget.php?&tw=1&pmid=32500379 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32500379 #FOAvip English Wikipedia <ref>{{Cite pmid|32500379}}</ref> COVID-19 and heme oxygenase: novel insight into the disease and potential therapies #MMPMID32500379 Hooper PL Cell Stress Chaperones 2020[Sep]; 25 (5): 707-710 PMID32500379show ga The COVID-19 pandemic needs therapies that are presently available and safe. We propose that subjects with metabolic syndrome, old age, and male gender have the greatest morbidity and mortality and have low stress proteins, in particular, low intracellular heme oxygenase (HO-1), making them particularly vulnerable to the disease. Additionally, COVID-19's heme reduction may contribute to even lower HO-1. Low-grade inflammation associated with these risk factors contributes to triggering a cytokine storm that spreads to multi-organ failure and near death. The high mortality of those treated with ventilator assistance may partially be explained by ventilator-induced inflammation. The cytoprotective and anti-inflammatory properties of HO-1 can limit the infection's damage. A paradox of COVID-19 hospital admissions data suggests that fewer cigarette-smokers are admitted compared with non-smokers in the general population. This unexpected observation may result from smoke induction of HO-1. Therapies with anti-viral properties that raise HO-1 include certain anesthetics (sevoflurane or isoflurane), hemin, estrogen, statins, curcumin, resveratrol, and melatonin. Controlled trials of these HO-1 inducers should be done in order to prevent or treat COVID-19 disease. |*Coronavirus Infections/epidemiology/immunology/therapy[MESH] |*Pandemics[MESH] |*Pneumonia, Viral/epidemiology/immunology/therapy[MESH] |*Smokers[MESH] |Age Factors[MESH] |Animals[MESH] |Antiviral Agents/therapeutic use[MESH] |COVID-19[MESH] |Cytokines/immunology[MESH] |Heat-Shock Proteins/immunology[MESH] |Heme Oxygenase-1/*physiology[MESH] |Humans[MESH] |Inflammation/immunology[MESH] |Male[MESH]COVID-19 and heme oxygenase: novel insight into the disease and potent(epmc).pdf DeepDyve Pubget Overpricing