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10.1136/ejhpharm-2020-002322

http://scihub22266oqcxt.onion/10.1136/ejhpharm-2020-002322
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32499314!7447248!32499314
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suck abstract from ncbi


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pmid32499314      Eur+J+Hosp+Pharm 2020 ; 27 (5): 297-298
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  • Involvement of interleukin 6 in SARS-CoV-2 infection: siltuximab as a therapeutic option against COVID-19 #MMPMID32499314
  • Palanques-Pastor T; Lopez-Briz E; Poveda Andres JL
  • Eur J Hosp Pharm 2020[Sep]; 27 (5): 297-298 PMID32499314show ga
  • The aim of the study was to explore the involvement of interleukin 6 in SARS-CoV-2 infection, and to position the drug siltuximab in the management of severe forms of COVID-19. A bibliographic search was performed in Pubmed on the immune response to the disease, and in ClinicalTrials.gov on clinical trials with interleukin 6 blockers. Interleukin 6 is involved in the cytokine cascade, which originates as a consequence of an excessive immune response secondary to viral infection, aggravating lung affectation. Blockers of this cytokine (tocilizumab, sarilumab and siltuximab) are being studied as a strategy for treating the disease. Siltuximab is a monoclonal antibody indicated in Castleman's disease that could be administered in a single dose of 11 mg/kg in severe forms of COVID-19 that have increased interleukin 6.
  • |Antibodies, Monoclonal/*therapeutic use[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*drug therapy/*metabolism[MESH]
  • |Drug Delivery Systems[MESH]
  • |Humans[MESH]
  • |Interleukin-6/*metabolism[MESH]
  • |Pandemics[MESH]


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