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10.1186/s40246-020-00272-6 http://scihub22266oqcxt.onion/10.1186/s40246-020-00272-6 32498696!7269898!32498696     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Hum+Genomics 2020 ; 14 (1): 20 Nephropedia Template TP {{tp|p=32498696|t=2020. COVID-19 preclinical models: human angiotensin-converting enzyme 2 transgenic mice |pdf=|usr=}}{{32498696}} gab.com Text COVID-19 preclinical models: human angiotensin-converting enzyme 2 transgenic mice JO: Hum Genomics http://www.kidney.de/pget.php?&tw=1&pmid=32498696 #FOAvip Coronavirus disease 2019 (COVID-19) is a declared pandemic that is spreading all over the world at a dreadfully fast rate. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the pathogen of COVID-19, infects the human body using angiotensin-converting enzyme 2 (ACE2) as a receptor identical to the severe acute respiratory syndrome (SARS) pandemic that occurred in 2002-2003. SARS-CoV-2 has a higher binding affinity to human ACE2 than to that of other species. Animal models that mimic the human disease are highly essential to develop therapeutics and vaccines against COVID-19. Here, we review transgenic mice that express human ACE2 in the airway and other epithelia and have shown to develop a rapidly lethal infection after intranasal inoculation with SARS-CoV, the pathogen of SARS. This literature review aims to present the importance of utilizing the human ACE2 transgenic mouse model to better understand the pathogenesis of COVID-19 and develop both therapeutics and vaccines. Twit Text FOAVip COVID-19 preclinical models: human angiotensin-converting enzyme 2 transgenic mice ????Hum Genomics http://www.kidney.de/pget.php?&tw=1&pmid=32498696 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32498696 #FOAvip English Wikipedia <ref>{{Cite pmid|32498696}}</ref> COVID-19 preclinical models: human angiotensin-converting enzyme 2 transgenic mice #MMPMID32498696 Lutz C; Maher L; Lee C; Kang W Hum Genomics 2020[Jun]; 14 (1): 20 PMID32498696show ga Coronavirus disease 2019 (COVID-19) is a declared pandemic that is spreading all over the world at a dreadfully fast rate. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the pathogen of COVID-19, infects the human body using angiotensin-converting enzyme 2 (ACE2) as a receptor identical to the severe acute respiratory syndrome (SARS) pandemic that occurred in 2002-2003. SARS-CoV-2 has a higher binding affinity to human ACE2 than to that of other species. Animal models that mimic the human disease are highly essential to develop therapeutics and vaccines against COVID-19. Here, we review transgenic mice that express human ACE2 in the airway and other epithelia and have shown to develop a rapidly lethal infection after intranasal inoculation with SARS-CoV, the pathogen of SARS. This literature review aims to present the importance of utilizing the human ACE2 transgenic mouse model to better understand the pathogenesis of COVID-19 and develop both therapeutics and vaccines. |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Betacoronavirus/*metabolism/pathogenicity[MESH] |COVID-19[MESH] |Coronavirus Infections/*pathology[MESH] |Disease Models, Animal[MESH] |Humans[MESH] |Mice[MESH] |Mice, Inbred C57BL[MESH] |Mice, Transgenic[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/*genetics/*metabolism[MESH] |Pneumonia, Viral/*pathology[MESH] |Promoter Regions, Genetic/genetics[MESH] |Protein Binding/physiology[MESH] |Receptors, Virus/genetics/metabolism[MESH]COVID-19 preclinical models: human angiotensin-converting enzyme 2 tra(epmc).pdf DeepDyve Pubget Overpricing