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10.1080/00325481.2020.1778982 http://scihub22266oqcxt.onion/10.1080/00325481.2020.1778982 32496926!7441788!32496926     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32496926&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Postgrad+Med 2020 ; 132 (7): 604-613 Nephropedia Template TP {{tp|p=32496926|t=2020. Advances in the use of chloroquine and hydroxychloroquine for the treatment of COVID-19 |pdf=|usr=}}{{32496926}} gab.com Text Advances in the use of chloroquine and hydroxychloroquine for the treatment of COVID-19 JO: Postgrad Med http://www.kidney.de/pget.php?&tw=1&pmid=32496926 #FOAvip Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading worldwide. Antiviral therapy is the most important treatment for COVID-19. Among the drugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19. CQ/HCQ were shown to prevent receptor recognition by coronaviruses, inhibit endosome acidification, which interferes with membrane fusion, and exhibit immunomodulatory activity. These multiple mechanisms may work together to exert a therapeutic effect on COVID-19. A number of in vitro studies revealed inhibitory effects of CQ/HCQ on various coronaviruses, including SARS-CoV-2 although conflicting results exist. Several clinical studies showed that CQ/HCQ alone or in combination with a macrolide may alleviate the clinical symptoms of COVID-19, promote viral conversion, and delay disease progression, with less serious adverse effects. However, recent studies indicated that the use of CQ/HCQ, alone or in combination with a macrolide, did not show any favorable effect on patients with COVID-19. Adverse effects, including prolonged QT interval after taking CQ/HCQ, may develop in COVID-19 patients. Therefore, current data are not sufficient enough to support the use of CQ/HCQ as therapies for COVID-19 and increasing caution should be taken about the application of CQ/HCQ in COVID-19 before conclusive findings are obtained by well-designed, multi-center, randomized, controlled studies. Twit Text FOAVip Advances in the use of chloroquine and hydroxychloroquine for the treatment of COVID-19 ????Postgrad Med http://www.kidney.de/pget.php?&tw=1&pmid=32496926 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32496926 #FOAvip English Wikipedia <ref>{{Cite pmid|32496926}}</ref> Advances in the use of chloroquine and hydroxychloroquine for the treatment of COVID-19 #MMPMID32496926 Sun J; Chen Y; Fan X; Wang X; Han Q; Liu Z Postgrad Med 2020[Sep]; 132 (7): 604-613 PMID32496926show ga Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is spreading worldwide. Antiviral therapy is the most important treatment for COVID-19. Among the drugs under investigation, anti-malarials, chloroquine (CQ) and hydroxychloroquine (HCQ), are being repurposed as treatment for COVID-19. CQ/HCQ were shown to prevent receptor recognition by coronaviruses, inhibit endosome acidification, which interferes with membrane fusion, and exhibit immunomodulatory activity. These multiple mechanisms may work together to exert a therapeutic effect on COVID-19. A number of in vitro studies revealed inhibitory effects of CQ/HCQ on various coronaviruses, including SARS-CoV-2 although conflicting results exist. Several clinical studies showed that CQ/HCQ alone or in combination with a macrolide may alleviate the clinical symptoms of COVID-19, promote viral conversion, and delay disease progression, with less serious adverse effects. However, recent studies indicated that the use of CQ/HCQ, alone or in combination with a macrolide, did not show any favorable effect on patients with COVID-19. Adverse effects, including prolonged QT interval after taking CQ/HCQ, may develop in COVID-19 patients. Therefore, current data are not sufficient enough to support the use of CQ/HCQ as therapies for COVID-19 and increasing caution should be taken about the application of CQ/HCQ in COVID-19 before conclusive findings are obtained by well-designed, multi-center, randomized, controlled studies. |Angiotensin-Converting Enzyme 2[MESH] |Antiviral Agents/pharmacology/*therapeutic use[MESH] |Betacoronavirus/drug effects/metabolism[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Chloroquine/pharmacology/*therapeutic use[MESH] |Coronavirus 229E, Human/drug effects[MESH] |Coronavirus Infections/*drug therapy[MESH] |Cytokines/drug effects/metabolism[MESH] |Glycosylation[MESH] |Humans[MESH] |Hydroxychloroquine/pharmacology/*therapeutic use[MESH] |Immunity, Innate[MESH] |In Vitro Techniques[MESH] |Long QT Syndrome/chemically induced[MESH] |Lymphocyte Activation/drug effects[MESH] |MAP Kinase Signaling System[MESH] |Middle East Respiratory Syndrome Coronavirus/drug effects[MESH] |Pandemics[MESH] |Peptidyl-Dipeptidase A/drug effects/metabolism[MESH] |Pneumonia, Viral/*drug therapy[MESH] |Reactive Oxygen Species[MESH] |SARS-CoV-2[MESH] |Severe acute respiratory syndrome-related coronavirus/drug effects[MESH] |Signal Transduction[MESH] |T-Lymphocytes[MESH] |Toll-Like Receptors/drug effects/metabolism[MESH] |Treatment Outcome[MESH]Advances in the use of chloroquine and hydroxychloroquine for the trea(epmc).pdf DeepDyve Pubget Overpricing