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10.1097/SHK.0000000000001574

http://scihub22266oqcxt.onion/10.1097/SHK.0000000000001574
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32496422!ä!32496422

suck abstract from ncbi


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pmid32496422      Shock 2020 ; 54 (5): 638-643
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  • Effects of Corticosteroid Treatment for Non-Severe COVID-19 Pneumonia: A Propensity Score-Based Analysis #MMPMID32496422
  • Yuan M; Xu X; Xia D; Tao Z; Yin W; Tan W; Hu Y; Song C
  • Shock 2020[Nov]; 54 (5): 638-643 PMID32496422show ga
  • BACKGROUND AND OBJECTIVE: The effects of corticosteroid treatment on non-severe COVID-19 pneumonia patients are unknown. To determine the impacts of adjuvant corticosteroid administrated to patients with non-severe COVID-19 pneumonia. METHOD: A retrospective cohort study based on propensity score analysis was designed to explore the effects of corticosteroid on several clinical outcomes. RESULTS: One hundred thirty-two patients satisfied the inclusion criteria and 35 pairs were generated according to propensity score matching. Compared to non-corticosteroid group, the CT score on day 7 was significantly higher in corticosteroid group (8.6 (interquartile range [IQR], 2.8-11.5) versus 12.0 (IQR, 5.0-19.3), P = 0.046). In corticosteroid group, more patients progressed to severe cases (11.4% versus 2.9%, P = 0.353), hospital stay (23.5 days (IQR, 19-29 d) versus 20.2 days (IQR, 14-25.3 d), P = 0.079) and duration of viral shedding (20.3 days (IQR, 15.2-24.8 d) versus 19.4 days (IQR, 11.5-28.3 d), P = 0.669) were prolonged, while fever time (9.5 days (IQR, 6.5-12.2 d) versus 10.2 days (IQR, 6.8-14 d), P = 0.28) was shortened; however, all these data revealed no statistically significant differences. CONCLUSION: Corticosteroid might have a negative effect on lung injury recovery in non-severe COVID-19 pneumonia patients; however, the results of this study must be interpreted with caution because of confounding factors.
  • |Adrenal Cortex Hormones/adverse effects/*therapeutic use[MESH]
  • |Adult[MESH]
  • |Aged[MESH]
  • |Betacoronavirus/*drug effects/pathogenicity[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/diagnosis/*drug therapy/virology[MESH]
  • |Disease Progression[MESH]
  • |Female[MESH]
  • |Host-Pathogen Interactions[MESH]
  • |Humans[MESH]
  • |Length of Stay[MESH]
  • |Lung/diagnostic imaging/*drug effects/virology[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Multidetector Computed Tomography[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/diagnosis/*drug therapy/virology[MESH]
  • |Propensity Score[MESH]
  • |Retrospective Studies[MESH]
  • |Risk Assessment[MESH]
  • |Risk Factors[MESH]
  • |SARS-CoV-2[MESH]
  • |Time Factors[MESH]
  • |Treatment Outcome[MESH]


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