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10.1097/TP.0000000000003339 http://scihub22266oqcxt.onion/10.1097/TP.0000000000003339 32496357!7302089!32496357     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32496357&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Transplantation 2020 ; 104 (11): 2208-2214 Nephropedia Template TP {{tp|p=32496357|t=2020. Early Experience With COVID-19 and Solid Organ Transplantation at a US High-volume Transplant Center |pdf=|usr=}}{{32496357}} gab.com Text Early Experience With COVID-19 and Solid Organ Transplantation at a US High-volume Transplant Center JO: Transplantation http://www.kidney.de/pget.php?&tw=1&pmid=32496357 #FOAvip BACKGROUND: The novel coronavirus severe acute respiratory syndrome coronavirus 2 [coronavirus disease 2019 (COVID-19)] poses unique challenges for immunosuppressed patients. Solid organ transplant (SOT) recipients comprise a large proportion of this group, yet there is limited knowledge about the presentation, clinical course, and immunosuppression management of this novel infection among heart, lung, liver, pancreas, and kidney transplant recipients. METHODS: We present 21 SOT recipients diagnosed with COVID-19 between January 1, 2020 and April 22, 2020 at a US high-volume transplant center. Diagnostic workup, clinical course, immunosuppression/antiviral management, and immediate outcomes are described. RESULTS: Twenty-one (15.9%) of 132 symptomatic patients tested were positive. Mean age at diagnosis was 54.8 +/- 10.9 y. Median time from transplant was 5.58 y (interquartile range 2.25, 7.33). Median follow-up was 18 d (interquartile range 13, 30). Fourteen patients required inpatient management, with 7 (50%) placed in the intensive care unit (ICU). All transplant types were represented. Nearly 43% exhibited GI symptoms. Over half (56.2%) presented with elevated serum creatinine suggestive of acute kidney injury. The majority of patients (5/7) with concomitant infections at baseline required the ICU. Eighty percent received hydroxychloroquine +/- azithromycin. Ten received toclizumab and/or ribavirin; 1 received remdesivir. Antimetabolites +/- calcineurin inhibitors were held or reduced. Over half of hospitalized patients (8/14) were discharged home. Only 1 mortality (4.8%) to date, in a critically ill heart/kidney patient who had been in the ICU before diagnosis. CONCLUSIONS: COVID-19 positive SOT at our institution had favorable short-term outcomes. Those with concomitant infections had more severe illness. More data will be available to evaluate long-term outcomes and disease impact on graft function. Twit Text FOAVip Early Experience With COVID-19 and Solid Organ Transplantation at a US High-volume Transplant Center ????Transplantation http://www.kidney.de/pget.php?&tw=1&pmid=32496357 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32496357 #FOAvip English Wikipedia <ref>{{Cite pmid|32496357}}</ref> Early Experience With COVID-19 and Solid Organ Transplantation at a US High-volume Transplant Center #MMPMID32496357 Yi SG; Rogers AW; Saharia A; Aoun M; Faour R; Abdelrahim M; Knight RJ; Grimes K; Bullock S; Hobeika M; McMillan R; Mobley C; Moaddab M; Huang HJ; Bhimaraj A; Ghobrial RM; Gaber AO Transplantation 2020[Nov]; 104 (11): 2208-2214 PMID32496357show ga BACKGROUND: The novel coronavirus severe acute respiratory syndrome coronavirus 2 [coronavirus disease 2019 (COVID-19)] poses unique challenges for immunosuppressed patients. Solid organ transplant (SOT) recipients comprise a large proportion of this group, yet there is limited knowledge about the presentation, clinical course, and immunosuppression management of this novel infection among heart, lung, liver, pancreas, and kidney transplant recipients. METHODS: We present 21 SOT recipients diagnosed with COVID-19 between January 1, 2020 and April 22, 2020 at a US high-volume transplant center. Diagnostic workup, clinical course, immunosuppression/antiviral management, and immediate outcomes are described. RESULTS: Twenty-one (15.9%) of 132 symptomatic patients tested were positive. Mean age at diagnosis was 54.8 +/- 10.9 y. Median time from transplant was 5.58 y (interquartile range 2.25, 7.33). Median follow-up was 18 d (interquartile range 13, 30). Fourteen patients required inpatient management, with 7 (50%) placed in the intensive care unit (ICU). All transplant types were represented. Nearly 43% exhibited GI symptoms. Over half (56.2%) presented with elevated serum creatinine suggestive of acute kidney injury. The majority of patients (5/7) with concomitant infections at baseline required the ICU. Eighty percent received hydroxychloroquine +/- azithromycin. Ten received toclizumab and/or ribavirin; 1 received remdesivir. Antimetabolites +/- calcineurin inhibitors were held or reduced. Over half of hospitalized patients (8/14) were discharged home. Only 1 mortality (4.8%) to date, in a critically ill heart/kidney patient who had been in the ICU before diagnosis. CONCLUSIONS: COVID-19 positive SOT at our institution had favorable short-term outcomes. Those with concomitant infections had more severe illness. More data will be available to evaluate long-term outcomes and disease impact on graft function. |*Immunocompromised Host[MESH] |*Transplant Recipients[MESH] |Adult[MESH] |Aged[MESH] |Betacoronavirus[MESH] |COVID-19[MESH] |Coronavirus Infections/*complications/*drug therapy[MESH] |Female[MESH] |Humans[MESH] |Immunosuppression Therapy[MESH] |Intensive Care Units[MESH] |Male[MESH] |Middle Aged[MESH] |Organ Transplantation[MESH] |Pandemics[MESH] |Pneumonia, Viral/*complications/*drug therapy[MESH] |SARS-CoV-2[MESH]Early Experience With COVID-19 and Solid Organ Transplantation at a US(epmc).pdf DeepDyve Pubget Overpricing