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Combination antiviral therapy with lopinavir/ritonavir, arbidol and interferon-alpha1b for COVID-19 #MMPMID32496210
Xie X; Jiang Y; Zeng Y; Liu H
Antivir Ther 2020[]; 25 (4): 233-239 PMID32496210show ga
Since the outbreak of coronavirus disease (COVID-19) that was discovered in 2019 in Wuhan, China, no standard therapy guideline has been set despite the severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its high infectivity. The globally pandemic outbreak suggests that COVID-19 is highly infectious and difficult to control. A dual-combination of ribavirin and interferon-alpha has been the widely used regimen for the treatment of this disease in China. However, due to the varying results of treatment with these drugs, a novel antiviral combination therapy is urgently needed. This case reports the usage of lopinavir/ritonavir-based combination antiviral regimen for a patient with SARS-CoV-2 infection.