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10.1111/dom.14105

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32496012!7300679!32496012
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suck abstract from ncbi


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pmid32496012      Diabetes+Obes+Metab 2020 ; 22 (10): 1907-1914
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  • Influence of diabetes mellitus on the severity and fatality of SARS-CoV-2 (COVID-19) infection #MMPMID32496012
  • Wu J; Zhang J; Sun X; Wang L; Xu Y; Zhang Y; Liu X; Dong C
  • Diabetes Obes Metab 2020[Oct]; 22 (10): 1907-1914 PMID32496012show ga
  • AIM: To evaluate the influence of diabetes on the severity and fatality of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. MATERIALS AND METHODS: The medical records of 66 hospitalized coronavirus disease 2019 (COVID-19) patients were collected and classified into non-severe (mild/moderate cases) and severe (severe/critical cases) groups. Logistic regression analysis was used to estimate the risk of severe COVID-19 (severe/critical infection). In addition, a meta-analysis including published studies reported the impact of diabetes on the severity and fatality of COVID-19. The current study was conducted using fixed effects models. RESULTS: There were 22 diabetes and 44 non-diabetes cases among the 66 hospitalized COVID-19 patients. Seven patients with diabetes (31.82%) were diagnosed as severe COVID-19 cases, which was significantly higher than that in the non-diabetes group (4/44, 9.09%, P = .033). After adjustment for age and gender, diabetes was significantly associated with COVID-19 severity (OR: 5.29, 95% CI: 1.07-26.02). A meta-analysis further confirmed the positive association between diabetes and COVID-19 severity (pooled OR = 2.58, 95% CI: 1.93-3.45). Moreover, the patients with diabetes infected with SARS-CoV-2 had a 2.95-fold higher risk of fatality compared with those patients without diabetes (95% CI: 1.93-4.53). CONCLUSIONS: Our findings provide new evidence that diabetes is associated with a higher risk of severity and fatality of COVID-19. Therefore, intensive monitoring and antidiabetic therapy should be considered in patients with diabetes with SARS-CoV-2 infection.
  • |Adult[MESH]
  • |Aged[MESH]
  • |COVID-19/complications/*mortality/*pathology/therapy[MESH]
  • |China/epidemiology[MESH]
  • |Diabetes Complications/epidemiology/mortality/pathology[MESH]
  • |Diabetes Mellitus/epidemiology/*mortality/pathology/therapy[MESH]
  • |Female[MESH]
  • |Hospitalization/statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Pandemics[MESH]
  • |SARS-CoV-2/physiology[MESH]


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