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10.26355/eurrev_202005_21374

http://scihub22266oqcxt.onion/10.26355/eurrev_202005_21374
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32495918!ä!32495918

suck abstract from ncbi


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pmid32495918      Eur+Rev+Med+Pharmacol+Sci 2020 ; 24 (10): 5797-5809
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  • Clinical characteristics of two human-to-human transmitted coronaviruses: Corona Virus Disease 2019 vs Middle East Respiratory Syndrome Coronavirus #MMPMID32495918
  • Xu P; Sun GD; Li ZZ
  • Eur Rev Med Pharmacol Sci 2020[May]; 24 (10): 5797-5809 PMID32495918show ga
  • OBJECTIVE: Subsequent to a global outbreak of the Middle East Respiratory Syndrome (MERS) in 2012, a novel human coronavirus, known as Corona Virus Disease 2019 (COVID-19) has caused a major disease outbreak. The aim of this study was to perform a systematic review to compare epidemiological, clinical, and laboratory features of COVID-19 and MERS-COV populations. MATERIALS AND METHODS: We searched PubMed, EMBASE, and Cochrane Central Register of Controlled Trials database to identify potential studies that have reported COVID-19 or MERS-COV disease. Epidemiology, clinical, and laboratory outcomes, intensive care unit (ICU) admission rates, discharge rates, and fatality rates were evaluated using Graph-Pad Prism software. RESULTS: A total of forty-two studies were included in our research, involving in 4,720 patients (COVID-19 = 2,012, MERS-COV = 2,708). The present study revealed that main clinical manifestations of both COVID-19 and MERS-COV populations are fever, cough and generalized weakness or myalgia, and Acute Respiratory Distress Syndrome (ARDS) is the main complication. The COVID-19 population has a lower rate of ICU admissions, discharges, fatalities, and shorter incubation periods than those of MERS-COV population. CONCLUSIONS: The main clinical features of both COVID-19 and MERS-COV populations are fever, cough and generalized weakness or myalgia. ARDS is the main complication of both populations. COVID-19 cases have a shorter incubation period and lower rate of ICU admissions, discharges and fatalities compared to MRES-COV population.
  • |Antiviral Agents/therapeutic use[MESH]
  • |Betacoronavirus/isolation & purification/*physiology[MESH]
  • |COVID-19[MESH]
  • |Comorbidity[MESH]
  • |Coronavirus Infections/drug therapy/*pathology/transmission/virology[MESH]
  • |Databases, Factual[MESH]
  • |Humans[MESH]
  • |Middle East Respiratory Syndrome Coronavirus/isolation & purification/*physiology[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/drug therapy/*pathology/transmission/virology[MESH]
  • |Respiratory Distress Syndrome/complications/diagnosis[MESH]
  • |SARS-CoV-2[MESH]


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