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10.1007/s40264-020-00955-y http://scihub22266oqcxt.onion/10.1007/s40264-020-00955-y 32495148!7269161!32495148     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Drug+Saf 2020 ; 43 (7): 657-660 Nephropedia Template TP {{tp|p=32495148|t=2020. A New Drug-Drug Interaction Between Hydroxychloroquine and Metformin? A Signal Detection Study |pdf=|usr=}}{{32495148}} gab.com Text A New Drug-Drug Interaction Between Hydroxychloroquine and Metformin A Signal Detection Study JO: Drug Saf http://www.kidney.de/pget.php?&tw=1&pmid=32495148 #FOAvip INTRODUCTION: Hydroxychloroquine was recently promoted in patients infected with COVID-19 infection. A recent experimental study has suggested an increased toxicity of hydroxychloroquine in association with metformin in mice. OBJECTIVE: The present study was undertaken to investigate the reality of this putative drug-drug interaction between hydroxychloroquine and metformin using pharmacovigilance data. METHODS: Using VigiBase((R)), the WHO pharmacovigilance database, we performed a disproportionality analysis (case/non-case study). Cases were reports of fatal outcomes with the drugs of interest and non-cases were all other reports for these drugs registered between 1 January 2000 and 31 December 2019. Data with hydroxychloroquine (or metformin) alone were compared with the association hydroxychloroquine + metformin. Results are reported as ROR (reporting odds ratio) with their 95% confidence interval. RESULTS: Of the 10,771 Individual Case Safety Reports (ICSR) involving hydroxychloroquine, 52 were recorded as 'fatal outcomes'. In comparison with hydroxychloroquine alone, hydroxychloroquine + metformin was associated with an ROR value of 57.7 (23.9-139.3). In comparison with metformin alone, hydroxychloroquine + metformin was associated with an ROR value of 6.0 (2.6-13.8). CONCLUSION: Our study identified a signal for the association hydroxychloroquine + metformin that appears to be more at risk of fatal outcomes (particularly by completed suicides) than one of the two drugs when given alone. Twit Text FOAVip A New Drug-Drug Interaction Between Hydroxychloroquine and Metformin A Signal Detection Study ????Drug Saf http://www.kidney.de/pget.php?&tw=1&pmid=32495148 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32495148 #FOAvip English Wikipedia <ref>{{Cite pmid|32495148}}</ref> A New Drug-Drug Interaction Between Hydroxychloroquine and Metformin? A Signal Detection Study #MMPMID32495148 Montastruc JL; Toutain PL Drug Saf 2020[Jul]; 43 (7): 657-660 PMID32495148show ga INTRODUCTION: Hydroxychloroquine was recently promoted in patients infected with COVID-19 infection. A recent experimental study has suggested an increased toxicity of hydroxychloroquine in association with metformin in mice. OBJECTIVE: The present study was undertaken to investigate the reality of this putative drug-drug interaction between hydroxychloroquine and metformin using pharmacovigilance data. METHODS: Using VigiBase((R)), the WHO pharmacovigilance database, we performed a disproportionality analysis (case/non-case study). Cases were reports of fatal outcomes with the drugs of interest and non-cases were all other reports for these drugs registered between 1 January 2000 and 31 December 2019. Data with hydroxychloroquine (or metformin) alone were compared with the association hydroxychloroquine + metformin. Results are reported as ROR (reporting odds ratio) with their 95% confidence interval. RESULTS: Of the 10,771 Individual Case Safety Reports (ICSR) involving hydroxychloroquine, 52 were recorded as 'fatal outcomes'. In comparison with hydroxychloroquine alone, hydroxychloroquine + metformin was associated with an ROR value of 57.7 (23.9-139.3). In comparison with metformin alone, hydroxychloroquine + metformin was associated with an ROR value of 6.0 (2.6-13.8). CONCLUSION: Our study identified a signal for the association hydroxychloroquine + metformin that appears to be more at risk of fatal outcomes (particularly by completed suicides) than one of the two drugs when given alone. |*Coronavirus Infections/diagnosis/drug therapy/epidemiology[MESH] |*Drug Interactions[MESH] |*Drug Therapy, Combination/adverse effects/mortality[MESH] |*Hydroxychloroquine/pharmacokinetics/therapeutic use[MESH] |*Metformin/pharmacokinetics/therapeutic use[MESH] |*Pandemics[MESH] |*Pneumonia, Viral/diagnosis/drug therapy/epidemiology[MESH] |Adult[MESH] |Adverse Drug Reaction Reporting Systems/statistics & numerical data[MESH] |Betacoronavirus/isolation & purification[MESH] |COVID-19[MESH] |Female[MESH] |Humans[MESH] |Hypoglycemic Agents/pharmacokinetics/therapeutic use[MESH] |Male[MESH] |Middle Aged[MESH] |Pharmacovigilance[MESH]A New Drug-Drug Interaction Between Hydroxychloroquine and Metformin? (epmc).pdf DeepDyve Pubget Overpricing