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10.1007/s00277-020-04103-5

http://scihub22266oqcxt.onion/10.1007/s00277-020-04103-5
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32495027!7266734!32495027
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  • Hematological findings in coronavirus disease 2019: indications of progression of disease #MMPMID32495027
  • Liu X; Zhang R; He G
  • Ann Hematol 2020[Jul]; 99 (7): 1421-1428 PMID32495027show ga
  • Coronavirus disease 2019 (COVID-19) is a new human infectious disease. The etiology for this outbreak is a novel coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Thus far, related research on COVID-19 is still in preliminary stage. This paper summarized the latest outcomes of corresponding study from Chinese centers and clarified the hematopoietic abnormality caused by SARS-CoV-2 and potential mechanism. Lymphopenia was common in the early stage after the onset of COVID-19. A significant decrease was observed in peripheral CD4+ and CD8+ T lymphocytes. As the illness progressed, neutrophilia emerged in several cases, and patients with severe critical pulmonary conditions showed higher neutrophils than common type. Thrombocytopenia was resulting from the consumption and/or the reduced production of platelets in damaged lungs. Anemia was not observed notably, but the decrease in hemoglobin was frequent. The activation of monocyte-macrophage system aggravates the immune damage of lung and other tissues, which leads to the increase of D-dimer, prothrombin time, and platelet consumption.
  • |*Betacoronavirus[MESH]
  • |*Disease Progression[MESH]
  • |CD4 Lymphocyte Count[MESH]
  • |CD8-Positive T-Lymphocytes[MESH]
  • |COVID-19[MESH]
  • |China[MESH]
  • |Coronavirus Infections/*blood/*immunology/pathology[MESH]
  • |Female[MESH]
  • |Hemoglobins/analysis[MESH]
  • |Humans[MESH]
  • |Leukocyte Count[MESH]
  • |Lung/immunology/pathology[MESH]
  • |Lymphopenia/virology[MESH]
  • |Male[MESH]
  • |Neutrophils[MESH]
  • |Pandemics[MESH]
  • |Pneumonia, Viral/*blood/*immunology/pathology[MESH]
  • |SARS-CoV-2[MESH]
  • |Thrombocytopenia/virology[MESH]


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  • suck abstract from ncbi

    1421 7.99 2020