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10.4049/jimmunol.2000380 http://scihub22266oqcxt.onion/10.4049/jimmunol.2000380 32493812!7343582!32493812     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2020 ; 205 (2): 313-320 Nephropedia Template TP {{tp|p=32493812|t=2020. Role of Aging and the Immune Response to Respiratory Viral Infections: Potential Implications for COVID-19 |pdf=|usr=}}{{32493812}} gab.com Text Role of Aging and the Immune Response to Respiratory Viral Infections: Potential Implications for COVID-19 JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32493812 #FOAvip Aging impairs immunity to promote diseases, especially respiratory viral infections. The current COVID-19 pandemic, resulting from SARS-CoV-2, induces acute pneumonia, a phenotype that is alarmingly increased with aging. In this article, we review findings of how aging alters immunity to respiratory viral infections to identify age-impacted pathways common to several viral pathogens, permitting us to speculate about potential mechanisms of age-enhanced mortality to COVID-19. Aging generally leads to exaggerated innate immunity, particularly in the form of elevated neutrophil accumulation across murine and large animal studies of influenza infection. COVID-19 patients who succumb exhibit a 2-fold increase in neutrophilia, suggesting that exaggerated innate immunity contributes to age-enhanced mortality to SARS-CoV-2 infection. Further investigation in relevant experimental models will elucidate the mechanisms by which aging impacts respiratory viral infections, including SARS-CoV-2. Such investigation could identify therapies to reduce the suffering of the population at large, but especially among older people, infected with respiratory viruses. Twit Text FOAVip Role of Aging and the Immune Response to Respiratory Viral Infections: Potential Implications for COVID-19 ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=32493812 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32493812 #FOAvip English Wikipedia <ref>{{Cite pmid|32493812}}</ref> Role of Aging and the Immune Response to Respiratory Viral Infections: Potential Implications for COVID-19 #MMPMID32493812 Chen J; Kelley WJ; Goldstein DR J Immunol 2020[Jul]; 205 (2): 313-320 PMID32493812show ga Aging impairs immunity to promote diseases, especially respiratory viral infections. The current COVID-19 pandemic, resulting from SARS-CoV-2, induces acute pneumonia, a phenotype that is alarmingly increased with aging. In this article, we review findings of how aging alters immunity to respiratory viral infections to identify age-impacted pathways common to several viral pathogens, permitting us to speculate about potential mechanisms of age-enhanced mortality to COVID-19. Aging generally leads to exaggerated innate immunity, particularly in the form of elevated neutrophil accumulation across murine and large animal studies of influenza infection. COVID-19 patients who succumb exhibit a 2-fold increase in neutrophilia, suggesting that exaggerated innate immunity contributes to age-enhanced mortality to SARS-CoV-2 infection. Further investigation in relevant experimental models will elucidate the mechanisms by which aging impacts respiratory viral infections, including SARS-CoV-2. Such investigation could identify therapies to reduce the suffering of the population at large, but especially among older people, infected with respiratory viruses. |Aging/*pathology[MESH] |Betacoronavirus/*physiology[MESH] |COVID-19[MESH] |Cardiovascular Diseases/pathology/virology[MESH] |Coronavirus Infections/*immunology/*pathology[MESH] |Cytokines/immunology[MESH] |Humans[MESH] |Influenza, Human/immunology/pathology[MESH] |Pandemics[MESH] |Pneumonia, Viral/*immunology/*pathology[MESH] |Respiratory Tract Infections/pathology/*virology[MESH] |SARS-CoV-2[MESH]Role of Aging and the Immune Response to Respiratory Viral Infections:(epmc).pdf DeepDyve Pubget Overpricing