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10.1016/j.arcmed.2020.05.013 http://scihub22266oqcxt.onion/10.1016/j.arcmed.2020.05.013 32493626!7241389!32493626     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Arch+Med+Res 2020 ; 51 (7): 718-720 Nephropedia Template TP {{tp|p=32493626|t=2020. S1 Subunit and Host Proteases as Potential Therapeutic Avenues for the Treatment of COVID-19 |pdf=|usr=}}{{32493626}} gab.com Text S1 Subunit and Host Proteases as Potential Therapeutic Avenues for the Treatment of COVID-19 JO: Arch Med Res http://www.kidney.de/pget.php?&tw=1&pmid=32493626 #FOAvip The novel corona virus (SARS-CoV-2) that causes severe acute respiratory syndrome, now called COVID-19 initially originated in Wuhan city of China and later spread across borders and infected more than five million people and killed over 3.4 lakh people all over the globe. This disease has been announced as pandemic by WHO. So far, there has been not much progress in terms of drug development for fighting against this deadliest virus, also no existing drugs has been reported completely effective for COVID-19 treatment owing to lack of effective therapeutic targets and a broad understanding of the viral behavior in target cell. Some reports have found and confirmed that SARS-CoV-2 like others SARS-CoVs utilizes angiotensin converting enzyme-2 receptor for making entry into target cell by binding to the receptor with its S1 subunit and employing host cell proteases for cleaving S2 subunit at S2' in order to fuse with cell membrane. Thus, simultaneous blocking of S1 subunit and inactivation of proteases seem to be promising therapeutic targets for the development of effective novel drugs. In current write up we hypothesize that S1 subunit and host proteases as potential therapeutic avenues for the treatment of COVID-19. Twit Text FOAVip S1 Subunit and Host Proteases as Potential Therapeutic Avenues for the Treatment of COVID-19 ????Arch Med Res http://www.kidney.de/pget.php?&tw=1&pmid=32493626 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32493626 #FOAvip English Wikipedia <ref>{{Cite pmid|32493626}}</ref> S1 Subunit and Host Proteases as Potential Therapeutic Avenues for the Treatment of COVID-19 #MMPMID32493626 Arafah A; Ali S; Yatoo AM; Ali MN; Rehman MU Arch Med Res 2020[Oct]; 51 (7): 718-720 PMID32493626show ga The novel corona virus (SARS-CoV-2) that causes severe acute respiratory syndrome, now called COVID-19 initially originated in Wuhan city of China and later spread across borders and infected more than five million people and killed over 3.4 lakh people all over the globe. This disease has been announced as pandemic by WHO. So far, there has been not much progress in terms of drug development for fighting against this deadliest virus, also no existing drugs has been reported completely effective for COVID-19 treatment owing to lack of effective therapeutic targets and a broad understanding of the viral behavior in target cell. Some reports have found and confirmed that SARS-CoV-2 like others SARS-CoVs utilizes angiotensin converting enzyme-2 receptor for making entry into target cell by binding to the receptor with its S1 subunit and employing host cell proteases for cleaving S2 subunit at S2' in order to fuse with cell membrane. Thus, simultaneous blocking of S1 subunit and inactivation of proteases seem to be promising therapeutic targets for the development of effective novel drugs. In current write up we hypothesize that S1 subunit and host proteases as potential therapeutic avenues for the treatment of COVID-19. |*Angiotensin-Converting Enzyme 2[MESH] |*COVID-19 Drug Treatment[MESH] |*SARS-CoV-2[MESH] |*Spike Glycoprotein, Coronavirus[MESH] |Antiviral Agents[MESH] |COVID-19/virology[MESH] |Drug Development[MESH] |Humans[MESH]S1 Subunit and Host Proteases as Potential Therapeutic Avenues for the(epmc).pdf DeepDyve Pubget Overpricing