Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1186/s12985-020-01342-w http://scihub22266oqcxt.onion/10.1186/s12985-020-01342-w 32493436!7267768!32493436     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Virol+J 2020 ; 17 (1): 71 Nephropedia Template TP {{tp|p=32493436|t=2020. Three kinds of treatment with Homoharringtonine, Hydroxychloroquine or shRNA and their combination against coronavirus PEDV in vitro |pdf=|usr=}}{{32493436}} gab.com Text Three kinds of treatment with Homoharringtonine, Hydroxychloroquine or shRNA and their combination against coronavirus PEDV in vitro JO: Virol J http://www.kidney.de/pget.php?&tw=1&pmid=32493436 #FOAvip BACKGROUND: Porcine epidemic diarrhea virus (PEDV) of the family Coronaviridae has caused substantial economic losses in the swine husbandry industry. There's currently no specific drug available for treatment of coronaviruses or PEDV. METHOD: In the current study, we use coronavirus PEDV as a model to study antiviral agents. Briefly, a fusion inhibitor tHR2, recombinant lentivirus-delivered shRNAs targeted to conserved M and N sequences, homoharringtonine (HHT), and hydroxychloroquine (HCQ) were surveyed for their antiviral effects. RESULTS: Treatment with HCQ at 50 muM and HHT at 150 nM reduced virus titer in TCID(50) by 30 and 3.5 fold respectively, and the combination reduced virus titer in TCID(50) by 200 fold. CONCLUSION: Our report demonstrates that the combination of HHT and HCQ exhibited higher antiviral activity than either HHT or HCQ exhibited. The information may contribute to the development of antiviral strategies effective in controlling PEDV infection. Twit Text FOAVip Three kinds of treatment with Homoharringtonine, Hydroxychloroquine or shRNA and their combination against coronavirus PEDV in vitro ????Virol J http://www.kidney.de/pget.php?&tw=1&pmid=32493436 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32493436 #FOAvip English Wikipedia <ref>{{Cite pmid|32493436}}</ref> Three kinds of treatment with Homoharringtonine, Hydroxychloroquine or shRNA and their combination against coronavirus PEDV in vitro #MMPMID32493436 Li CC; Wang XJ Virol J 2020[Jun]; 17 (1): 71 PMID32493436show ga BACKGROUND: Porcine epidemic diarrhea virus (PEDV) of the family Coronaviridae has caused substantial economic losses in the swine husbandry industry. There's currently no specific drug available for treatment of coronaviruses or PEDV. METHOD: In the current study, we use coronavirus PEDV as a model to study antiviral agents. Briefly, a fusion inhibitor tHR2, recombinant lentivirus-delivered shRNAs targeted to conserved M and N sequences, homoharringtonine (HHT), and hydroxychloroquine (HCQ) were surveyed for their antiviral effects. RESULTS: Treatment with HCQ at 50 muM and HHT at 150 nM reduced virus titer in TCID(50) by 30 and 3.5 fold respectively, and the combination reduced virus titer in TCID(50) by 200 fold. CONCLUSION: Our report demonstrates that the combination of HHT and HCQ exhibited higher antiviral activity than either HHT or HCQ exhibited. The information may contribute to the development of antiviral strategies effective in controlling PEDV infection. |Animals[MESH] |Antiviral Agents/*pharmacology[MESH] |Chlorocebus aethiops[MESH] |Coronavirus Infections/drug therapy/prevention & control/virology[MESH] |Coronavirus M Proteins[MESH] |Coronavirus Nucleocapsid Proteins[MESH] |Drug Synergism[MESH] |Homoharringtonine/*pharmacology[MESH] |Hydroxychloroquine/*pharmacology[MESH] |Nucleocapsid Proteins/genetics[MESH] |Peptides/pharmacology[MESH] |Porcine epidemic diarrhea virus/*drug effects[MESH] |RNA, Small Interfering/genetics/*pharmacology[MESH] |Spike Glycoprotein, Coronavirus/antagonists & inhibitors/chemistry[MESH] |Vero Cells[MESH] |Viral Load/drug effects[MESH]Three kinds of treatment with Homoharringtonine, Hydroxychloroquine or(epmc).pdf DeepDyve Pubget Overpricing